Simple Summary The cancer-immunity cycle is characterized by various stimulatory and
inhibitory factors, which together regulate the immune response and halt the extreme …

Two conceptually unique approaches are currently available for the production of human
monoclonal antibodiesthe'hybridoma'technique, based on the fusion of antibody-producing …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

We have created mouse-human antibody molecules of defined antigen-binding specificity
by taking the variable region genes of a mouse antibody-producing myeloma cell line with …

Controlled Drug Delivery Page 1 Controlled Drug Delivery Page 2 DRUGS AND THE
PHARMACEUTICAL SCIENCES A Series of Textbooks and Monographs Edited by James …

Human anti-murine immunoglobulin responses were assessed in serum from three groups
of patients receiving murine monoclonal antibody therapy. Each of the three patient groups …

The murine IgG3 monoclonal antibody (MoAb) 3F8, specific for the ganglioside GD2,
activates human complement, is active in antibody-dependent cell-mediated cytotoxicity …

Monoclonal antibodies (MoAbs) were raised against epidermal growth factor (EGF)
receptors on a human epidermoid carcinoma cell line, A431. Administration of anti-EGF …

A major aim in immunology has been to understand how the immune system evokes
characteristic responses to infection, foreign tissue grafts and tumours. The current view of …

Using the fluorescence activated cell sorter to select rare IgG2a-and IgG2b-producing
variants, we developed switch variant families of hybridomas from IgG1-producing …