Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of
p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent …

Fanconi anemia (FA) is a complex genetic disorder characterized by bone marrow failure
(BMF), congenital defects, inability to repair DNA interstrand cross-links (ICLs), and cancer …

Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …

Fanconi anemia (FA) is a genomic instability syndrome with predisposition to congenital
abnormalities, bone marrow failure, and cancer. Classical and most frequent congenital …

The WD40-containing E3 ubiquitin ligase RFWD3 has been recently linked to the repair of
DNA damage by homologous recombination (HR). Here we have shown that an RFWD3 …

Repair of DNA interstrand crosslinks requires action of multiple DNA repair pathways,
including homologous recombination. Here, we report a de novo heterozygous T131P …

Fanconi Anemia (FA) is a debilitating genetic disorder with a wide range of severe
symptoms including bone marrow failure and predisposition to cancer. CRISPR-Cas …

Head and neck (HN) squamous cell carcinomas (SCCs) originate from the epithelial cells of
the mucosal linings of the upper aerodigestive tract, which includes the oral cavity, the …

Abstract The US Food and Drug Administration recently approved two poly‐adenosine
diphosphate‐ribose polymerase (PARP) inhibitors, olaparib and rucaparib, for treatment of …

The key problem in human infectious diseases was posed at the turn of the 20th century:
their pathogenesis. For almost any given virus, bacterium, fungus, or parasite, life …