Clinical significance of hepatitis C virus genotypes and quasispecies.

P Farci, RH Purcell - Seminars in liver disease, 2000 - europepmc.org
Hepatitis C virus (HCV) is a major cause of morbidity and mortality worldwide. The infection
becomes chronic in about 85% of infected individuals, in the face of a strong humoral and …

Extrahepatic disease manifestations of HCV infection: some current issues

V Agnello, FG De Rosa - Journal of hepatology, 2004 - Elsevier
Productive hepatitis C virus (HCV) infection appears to be primarily, and in most patients
almost exclusively, confined to the liver. However, a wide variety of extrahepatic disease …

[PDF][PDF] Persistence of hepatitis C virus in patients successfully treated for chronic hepatitis C

M Radkowski, JF Gallegos‐Orozco, J Jablonska… - …, 2005 - Wiley Online Library
It is unclear whether the current antiviral treatment for chronic hepatitis C virus (HCV)
infection results in complete elimination of the virus, or whether small quantities of virus …

Search for hepatitis C virus negative-strand RNA sequences and analysis of viral sequences in the central nervous system: evidence of replication

M Radkowski, J Wilkinson, M Nowicki, D Adair… - Journal of …, 2002 - Am Soc Microbiol
Patients with chronic hepatitis C are more likely to have significant changes in their physical
and mental well-being than patients with liver disease of other etiology, and hepatitis C virus …

Identification of unique hepatitis C virus quasispecies in the central nervous system and comparative analysis of internal translational efficiency of brain, liver, and …

DM Forton, P Karayiannis, N Mahmud… - Journal of …, 2004 - Am Soc Microbiol
Reports of cerebral dysfunction in chronic hepatitis C virus (HCV) infection have led to the
suggestion that HCV may infect the central nervous system (CNS). We used reverse …

Hepatitis C virus neuroinvasion: identification of infected cells

J Wilkinson, M Radkowski, T Laskus - Journal of virology, 2009 - Am Soc Microbiol
Hepatitis C virus (HCV) infection often is associated with cognitive dysfunction and
depression. HCV sequences and replicative forms were detected in autopsy brain tissue …

Hepatitis C virus particles and lipoprotein metabolism

P André, G Perlemuter, A Budkowska… - Seminars in liver …, 2005 - thieme-connect.com
The majority of infectious hepatitis C particles are present in the low-density fractions from
plasma of infected patients, suggesting an association of the virus with lipoproteins and the …

[PDF][PDF] Extrahepatic replication of HCV: insights into clinical manifestations and biological consequences

JT Blackard, N Kemmer, KE Sherman - Hepatology, 2006 - Wiley Online Library
An estimated 170 million persons are infected with the hepatitis C virus (HCV) worldwide.
While hepatocytes are the major site of infection, a broad clinical spectrum of extrahepatic …

Hepatitis C virus in lymphoid cells of patients coinfected with human immunodeficiency virus type 1: evidence of active replication in monocytes/macrophages and …

T Laskus, M Radkowski, A Piasek… - The Journal of …, 2000 - academic.oup.com
It has been reported that hepatitis C virus (HCV) may be lymphotropic in the setting of
human immunodeficiency virus type 1 (HIV-1) coinfection. The present study was …

Neuropsychiatric impact of hepatitis C on advanced HIV

EL Ryan, S Morgello, K Isaacs, M Naseer, P Gerits… - Neurology, 2004 - AAN Enterprises
Objective: To determine whether hepatitis C (HCV) contributes to CNS dysfunction among
HIV-infected individuals. Methods: Using a cross-sectional design, the neuropsychiatric …