Trends in kinase drug discovery: targets, indications and inhibitor design
The FDA approval of imatinib in 2001 was a breakthrough in molecularly targeted cancer
therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology …
therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology …
Functional roles of JNK and p38 MAPK signaling in nasopharyngeal carcinoma
c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members integrate signals that affect proliferation, differentiation, survival, and migration in a …
members integrate signals that affect proliferation, differentiation, survival, and migration in a …
Role of c-Jun N-terminal kinase (JNK) in obesity and type 2 diabetes
JHM Yung, A Giacca - Cells, 2020 - mdpi.com
Obesity has been described as a global epidemic and is a low-grade chronic inflammatory
disease that arises as a consequence of energy imbalance. Obesity increases the risk of …
disease that arises as a consequence of energy imbalance. Obesity increases the risk of …
Selective inhibitors for JNK signalling: a potential targeted therapy in cancer
Q Wu, W Wu, V Jacevic, TCC Franca… - Journal of enzyme …, 2020 - Taylor & Francis
Abstract c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and
survival. Emerging evidence show that JNK promoted tumour progression is involved in …
survival. Emerging evidence show that JNK promoted tumour progression is involved in …
Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model
JE La Marca, HE Richardson - Frontiers in cell and developmental …, 2020 - frontiersin.org
The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has many
functions, regulating a diversity of processes: from cell movement during embryogenesis to …
functions, regulating a diversity of processes: from cell movement during embryogenesis to …
The role of stress kinases in metabolic disease
Obesity is a health condition that has reached pandemic levels and is implicated in the
development and progression of type 2 diabetes mellitus, cancer and heart failure. A key …
development and progression of type 2 diabetes mellitus, cancer and heart failure. A key …
JNK pathway in CNS pathologies
T de los Reyes Corrales, M Losada-Pérez… - International journal of …, 2021 - mdpi.com
The c-Jun N-terminal kinase (JNK) signalling pathway is a conserved response to a wide
range of internal and external cellular stress signals. Beside the stress response, the JNK …
range of internal and external cellular stress signals. Beside the stress response, the JNK …
c-Jun N-terminal kinases (JNKs) in myocardial and cerebral ischemia/reperfusion injury
M Shvedova, Y Anfinogenova… - Frontiers in …, 2018 - frontiersin.org
In this article, we review the literature regarding the role of c-Jun N-terminal kinases (JNKs)
in cerebral and myocardial ischemia/reperfusion injury. Numerous studies demonstrate that …
in cerebral and myocardial ischemia/reperfusion injury. Numerous studies demonstrate that …
Comparison of clinical features and outcomes between intrahepatic cholangiocarcinoma and hepatocellular carcinoma in the United States
Background and Aims Intrahepatic cholangiocarcinoma (iCCA) and hepatocellular
carcinoma (HCC) are the most common primary liver cancers (PLCs). Differences in their …
carcinoma (HCC) are the most common primary liver cancers (PLCs). Differences in their …
Synthesis, biological evaluation, and molecular modeling of 11H-indeno [1, 2-b] quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase …
IA Schepetkin, AI Khlebnikov, AS Potapov… - European journal of …, 2019 - Elsevier
Abstract c-Jun N-terminal kinases (JNKs) play a central role in many physiologic and
pathologic processes. We synthesized novel 11 H-indeno [1, 2-b] quinoxalin-11-one oxime …
pathologic processes. We synthesized novel 11 H-indeno [1, 2-b] quinoxalin-11-one oxime …