Wasp venom-induced acute kidney injury: current progress and prospects

F Yu, L Wang, H Yuan, Z Gao, L He, F Hu - Renal Failure, 2023 - Taylor & Francis
Wasp venom can trigger local and systemic reactions, with the kidneys being commonly
affected, potentially causing acute kidney injury (AKI). Despite of the recent advances, our …

Impact of chemical modifications on the antimicrobial and hemolytic activity of helical amphipathic peptide Lasioglossin LL-III

H Bui Thi Phuong, C Le Uyen, H Doan Ngan… - Amino Acids, 2023 - Springer
Insect venom is abundant in potential antimicrobial peptides (AMPs), which can serve as
novel alternatives to conventional antibiotics. Among them, Lasioglossin III LL-III) is a …

Employment of mastoparan-like peptides to prevent Staphylococcus aureus associated with bovine mastitis

RMQ Orozco, KGN Oshiro, IB Pinto… - Journal of …, 2024 - Am Soc Microbiol
Bovine mastitis is a frequent infection in lactating cattle, causing great economic losses.
Staphylococcus aureus represents the main etiological agent, which causes recurrent and …

Deciphering the structure and mechanism of action of computer‐designed mastoparan peptides

KGN Oshiro, CDP Freitas, SB Rezende… - The FEBS …, 2024 - Wiley Online Library
Mastoparans are cationic peptides with multifunctional pharmacological properties.
Mastoparan‐R1 and mastoparan‐R4 were computationally designed based on native …

[HTML][HTML] Unwrapping the structural and functional features of antimicrobial peptides from wasp venoms

HM Duque, C Dos Santos, J Brango-Vanegas… - Pharmacological …, 2024 - Elsevier
The study of wasp venoms has captured attention due to the presence of a wide variety of
active compounds, revealing a diverse array of biological effects. Among these compounds …

A review on genotoxic and genoprotective effects of biologically active compounds of animal origin

N Sjakste, G Gajski - Toxins, 2023 - mdpi.com
Envenomation by animal venoms remains a serious medical and social problem, especially
in tropical countries. On the other hand, animal venoms are widely used as a source of …

Influence of hydrophobicity on the antimicrobial activity of helical antimicrobial peptides: a study focusing on three mastoparans

B Le Huy, HBT Phuong, BNT Thanh, QT Van… - Molecular Diversity, 2024 - Springer
Hydrophobicity is crucial for the interaction between amphipathic antimicrobial peptides and
microbial pathogens. However, it is difficult to fully understand the impact of this factor …

Characterization of the Hemolytic Activity of Mastoparan Family Peptides from Wasp Venoms

X Ye, H Zhang, X Luo, F Huang, F Sun, L Zhou, C Qin… - Toxins, 2023 - mdpi.com
Biologically active peptides have attracted increasing attention in research on the
development of new drugs. Mastoparans, a group of wasp venom linear cationic α-helical …

Amphiphilic peptide Mastoparan‐B induces conformational changes within the AdeB efflux pump, down‐regulates adeB gene expression, and restores antibiotic susceptibility in …

MR Shakibaie, F Modaresi, O Azizi… - Proteins: Structure …, 2023 - Wiley Online Library
Abstract Mastoparan B (MP‐B) is an amphiphilic peptide with a potent antimicrobial activity
against most Gram‐negative bacteria. However, there is little information available on the …

The amphipathic design in helical antimicrobial peptides

H Bui Thi Phuong, H Doan Ngan, B Le Huy… - …, 2024 - Wiley Online Library
Amphipathicity is a critical characteristic of helical antimicrobial peptides (AMPs). The
hydrophilic region, primarily composed of cationic residues, plays a pivotal role in the initial …