Extracellular neuritic plaques composed of amyloid‑β (Aβ) protein and intracellular
neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

We recommend a new term,“primary age-related tauopathy”(PART), to describe a pathology
that is commonly observed in the brains of aged individuals. Many autopsy studies have …

Abnormal tau lesions (non-argyrophilic pretangle material, argyrophilic neuropil threads,
neurofibrillary tangles) in select types of neurons are crucial for the pathogenesis of sporadic …

Two thousand three hundred and thirty two nonselected brains from 1-to 100-year-old
individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for …

Introduction Alzheimer's disease (AD) progression follows a specific spreading pattern,
emphasizing the need to characterize those brain areas that degenerate first. The …

Neurodegenerative diseases (NDDs) are characterized by selective dysfunction and loss of
neurons associated with pathologically altered proteins that deposit in the human brain but …

Neurodegenerative diseases are characterised by selective dysfunction and progressive
loss of synapses and neurons associated with pathologically altered proteins that deposit …

Brains of 42 individuals between the ages of 4 and 29 were examined with antibodies (AT8,
4G8) and silver stains for the presence of intraneuronal and extracellular protein aggregates …

Resting-state or intrinsic connectivity network functional magnetic resonance imaging
provides a new tool for mapping large-scale neural network function and dysfunction …