Given the unprecedented tools that are now available for rapidly comparing genomes, the
identification and study of genetic and genomic changes that are unique to our species have …

Hepatitis C Virus (HCV) infection is a global public health problem affecting over 160 million
individuals worldwide. Its symptoms include chronic hepatitis, liver cirrhosis and …

Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma.
Current antiviral therapy fails to clear infection in a substantial proportion of cases. Drug …

Objectives Filoviruses such as Ebola virus and Marburg virus cause a severe haemorrhagic
fever syndrome in humans for which there is no specific treatment. Since filoviruses use a …

Hepatitis C virus (HCV) predominantly infects human hepatocytes, although extrahepatic
virus reservoirs are being discussed. Infection of cells is initiated via cell-free and direct cell …

Due to the obligatory intracellular lifestyle of viruses, cell culture systems for efficient viral
propagation are crucial to obtain a detailed understanding of the virus–host cell interaction …

Hepatitis C virus (HCV) is believed to initially infect the liver through the basolateral side of
hepatocytes, where it engages attachment factors and the coreceptors CD81 and scavenger …

SUMMARY HCV is a blood‐borne pathogen that affects approximately 3% of the global
population and leads to progressive liver disease. Recent advances have identified an …

Hepatitis C virus (HCV) is one of very few viruses that are either naturally cleared, or
alternatively persist to cause chronic disease. Viral diversity and escape, as well as host …

Hepatitis C virus (HCV) successfully evades the immune system and establishes chronic
infection in∼ 80% of cases. Immune evasion may involve modulating NK cell functions …