The emerging complexity of gene fusions in cancer
F Mertens, B Johansson, T Fioretos… - Nature Reviews Cancer, 2015 - nature.com
Structural chromosome rearrangements may result in the exchange of coding or regulatory
DNA sequences between genes. Many such gene fusions are strong driver mutations in …
DNA sequences between genes. Many such gene fusions are strong driver mutations in …
Mechanisms of neuroblastoma regression
GM Brodeur, R Bagatell - Nature reviews Clinical oncology, 2014 - nature.com
Recent genomic and biological studies of neuroblastoma have shed light on the dramatic
heterogeneity in the clinical behaviour of this disease, which spans from spontaneous …
heterogeneity in the clinical behaviour of this disease, which spans from spontaneous …
New brain tumor entities emerge from molecular classification of CNS-PNETs
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young …
aggressive, poorly differentiated embryonal tumors occurring predominantly in young …
Cancer genetics and genomics of human FOX family genes
M Katoh, M Igarashi, H Fukuda, H Nakagama, M Katoh - Cancer letters, 2013 - Elsevier
Forkhead-box (FOX) family proteins, involved in cell growth and differentiation as well as
embryogenesis and longevity, are DNA-binding proteins regulating transcription and DNA …
embryogenesis and longevity, are DNA-binding proteins regulating transcription and DNA …
11q deletion in neuroblastoma: a review of biological and clinical implications
V Mlakar, S Jurkovic Mlakar, G Lopez, JM Maris… - Molecular cancer, 2017 - Springer
Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events
that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is …
that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is …
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis
EP Rahrmann, AL Watson, VW Keng, K Choi… - Nature …, 2013 - nature.com
Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas of Schwann cell lineage
origin that occur sporadically or in association with the inherited syndrome …
origin that occur sporadically or in association with the inherited syndrome …
The dominant role of forkhead box proteins in cancer
Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly
implicated in cancer, with various critical roles in biological processes. Herein, we provide …
implicated in cancer, with various critical roles in biological processes. Herein, we provide …
FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with a
highly variable prognosis. Activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway …
highly variable prognosis. Activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway …
Common co-activation of AXL and CDCP1 in EGFR-mutation-positive non-small cell lung cancer associated with poor prognosis
N Karachaliou, I Chaib, AF Cardona, J Berenguer… - …, 2018 - thelancet.com
Epidermal growth factor receptor (EGFR)-mutation-positive non-small cell lung cancer
(NSCLC) is incurable, despite high rates of response to EGFR tyrosine kinase inhibitors …
(NSCLC) is incurable, despite high rates of response to EGFR tyrosine kinase inhibitors …