New and consolidated therapeutic options for pubertal induction in hypogonadism: in-depth review of the literature

S Federici, G Goggi, R Quinton, L Giovanelli… - Endocrine …, 2022 - academic.oup.com
Delayed puberty (DP) defines a retardation of onset/progression of sexual maturation
beyond the expected age from either a lack/delay of the hypothalamo-pituitary-gonadal axis …

The clinical and biochemical significance of 11-oxygenated androgens in human health and disease

KH Storbeck, MW O'Reilly - European Journal of Endocrinology, 2023 - academic.oup.com
For many decades, the prevailing paradigm in endocrinology was that testosterone and 5α-
dihydrotestosterone are the only potent androgens in the context of human physiology. The …

Endocrine disruptors and prostate cancer

M Corti, S Lorenzetti, A Ubaldi, R Zilli… - International Journal of …, 2022 - mdpi.com
The role of endocrine disruptors (EDs) in the human prostate gland is an overlooked issue
even though the prostate is essential for male fertility. From experimental models, it is known …

A quantitative analysis of total and free 11-oxygenated androgens and its application to human serum and plasma specimens using liquid-chromatography tandem …

P Caron, V Turcotte, C Guillemette - Journal of Chromatography A, 2021 - Elsevier
Abstract Bioactive 11-oxygenated C 19 adrenal-derived steroids (11-oxy C 19) are
potentially relevant in diverse endocrine and metabolic contexts. We report the development …

Bioactivity of 11 keto and hydroxy androgens in yeast and mammalian host cells

DJ Handelsman, ER Cooper, AK Heather - The Journal of steroid …, 2022 - Elsevier
Recent studies have highlighted the potential role of 11oxygenated (keto or hydroxy)
androgens in human reproductive function with 11keto androgens circulating at …

The association of testosterone with sarcopenia and frailty in chronic liver disease

L Chrysavgis, M Adamantou… - European Journal of …, 2024 - Wiley Online Library
Background Testosterone is an important anabolic hormone responsible for maintaining
body composition and muscle mass and circulates mostly albumin‐bound, or sex hormone …

Predictors of reproductive and non-reproductive outcomes of gonadotropin mediated pubertal induction in male patients with congenital hypogonadotropic …

B Cangiano, G Goggi, S Federici, C Bresesti… - Journal of …, 2021 - Springer
Purpose To investigate predictors of testicular response and non-reproductive outcomes
(height, body proportions) after gonadotropin-induced puberty in congenital …

From subjective to objective: a pilot study on testicular radiomics analysis as a measure of gonadal function

B De Santi, G Spaggiari, ARM Granata, M Romeo… - …, 2022 - Wiley Online Library
Background The connection between testicular ultrasound (US) parameters and testicular
function, including both spermato‐and steroidogenesis has been largely suggested, but …

[HTML][HTML] Quantitative analysis of 34 sex (Pro) hormones, conjugates and bioactive oxidation products thereof in human plasma by GC-and LC-MS/MS and systematic …

M Raps, C Kleider, L Lehmann - Steroids, 2024 - Elsevier
When investigating endocrine disorders, it is essential to assess a comprehensive
quantitative profile of sex (pro) hormones in plasma including conjugates. Thus, the present …

Association of Atrazine-Induced Overexpression of Aldo–Keto-Reductase 1C2 (AKR1C2) with Hypoandrogenism and Infertility: An Experimental Study in Male Wistar …

AM Arulanandu, V Kalimuthu, SC Manimegalai… - Reproductive …, 2024 - Springer
Abstract Atrazine (ATZ, C8H14ClN5) is a widely used synthetic herbicide that contaminates
drinking water. It is a known endocrine disruptor that disrupts various molecular pathways …