Zinc as a gatekeeper of immune function

I Wessels, M Maywald, L Rink - Nutrients, 2017 - mdpi.com
After the discovery of zinc deficiency in the 1960s, it soon became clear that zinc is essential
for the function of the immune system. Zinc ions are involved in regulating intracellular …

Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies

CA Curcio - Investigative ophthalmology & visual science, 2018 - iovs.arvojournals.org
AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration

M Menon, S Mohammadi, J Davila-Velderrain… - Nature …, 2019 - nature.com
Genome-wide association studies (GWAS) have identified genetic variants associated with
age-related macular degeneration (AMD), one of the leading causes of blindness in the …

Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration

ACS Tan, MG Pilgrim, S Fearn, S Bertazzo… - Science translational …, 2018 - science.org
Drusen are lipid-, mineral-, and protein-containing extracellular deposits that accumulate
between the basal lamina of the retinal pigment epithelium (RPE) and Bruch's membrane …

[HTML][HTML] The clinical relevance of visualising the peripheral retina

N Quinn, L Csincsik, E Flynn, CA Curcio, S Kiss… - Progress in retinal and …, 2019 - Elsevier
Recent developments in imaging technologies now allow the documentation, qualitative and
quantitative evaluation of peripheral retinal lesions. As wide field retinal imaging, capturing …

On the origin of proteins in human drusen: The meet, greet and stick hypothesis

AA Bergen, S Arya, C Koster, MG Pilgrim… - Progress in Retinal and …, 2019 - Elsevier
Retinal drusen formation is not only a clinical hallmark for the development of age-related
macular degeneration (AMD) but also for other disorders, such as Alzheimer's disease and …

[HTML][HTML] Subretinal pigment epithelial deposition of drusen components including hydroxyapatite in a primary cell culture model

MG Pilgrim, I Lengyel, A Lanzirotti… - … & visual science, 2017 - arvojournals.org
Purpose: Extracellular deposits containing hydroxyapatite, lipids, proteins, and trace metals
that form between the basal lamina of the RPE and the inner collagenous layer of Bruch's …

Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye

RB Thompson, V Reffatto, JG Bundy… - Proceedings of the …, 2015 - National Acad Sciences
Accumulation of protein-and lipid-containing deposits external to the retinal pigment
epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of …

Zinc nutrition and inflammation in the aging retina

R Gilbert, T Peto, I Lengyel… - Molecular nutrition & food …, 2019 - Wiley Online Library
Zinc is an essential nutrient for human health. It plays key roles in maintaining protein
structure and stability, serves as catalytic factor for many enzymes, and regulates diverse …

The impact of 25-hydroxyvitamin D and calcium on risk of age-related macular degeneration: a Mendelian randomization study

XX Dong, DL Chen, YF Miao, DL Li, JY Kai… - The American Journal of …, 2024 - Elsevier
Background The relationships between 25-hydroxyvitamin D [25 (OH) D] and calcium and
age-related macular degeneration (AMD) are unclear. Objectives This study aimed to …