Eosinophils are important effector cells and therapeutic targets in allergic diseases.
Emerging data indicate that eosinophils infiltrate a variety of solid tumor types and have …

Eosinophils are a prominent cell type in particular host responses such as the response to
helminth infection and allergic disease. Their effector functions have been attributed to their …

Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …

Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

Eosinophils can regulate local immune and inflammatory responses, and their accumulation
in the blood and tissue is associated with several inflammatory and infectious diseases …

Receptors carrying immunoreceptor tyrosine‐based inhibition motifs (ITIMs) in their
cytoplasmic tail control a vast array of cellular responses, ranging from autoimmunity …

The CD300 family of molecules modulates a broad and diverse array of immune cell
processes via their paired activating and inhibitory receptor functions. The description that …

The respective life histories of human subjects and mice are well defined and describe a
unique story of evolutionary conservation extending from sequence identity within the …

Chronic spontaneous urticaria (CSU) is considered to be primarily a mast cell–driven
disease. However, recent evidence suggests that eosinophils may also have an axial role in …

Mast cells are powerful immune modulators of the tissue microenvironment. Within seconds
of activation, these cells release a variety of preformed biologically active products, followed …