Diarylethene (DAE) photoswitches, known for their reversible photoinduced cyclization and
cycloreversion reactions, have shown great promise in various fields such as optical data …

The field of photopharmacology uses molecular photoswitches to establish control over the
action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of …

AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Acetylcholinesterase (AChE) inhibitor is the first choice for the treatment of Alzheimer's
disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term …

Alzheimer's disease (AD) is a progressive neurological illness that causes dementia mainly
in the elderly. The challenging obstacles related to AD has freaked global healthcare system …

The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …

To develop tools to investigate the biological functions of butyrylcholinesterase (BChE) and
the mechanisms by which BChE affects Alzheimer's disease (AD), we synthesized several …

Photopharmacology relies on ligands that change their pharmacodynamics upon
photoisomerization. Many of these ligands are azobenzenes that are thermodynamically …

We present the synthesis and characterization of merged human butyrylcholinesterase (h
BChE) inhibitor/cannabinoid receptor 2 (h CB2R) ligands for the treatment of …

The success of photopharmacology is inevitably tied to the availability of photoswitches,
which can be operated within the biological window (λ= 650–1450 nm) to maximize …