Photoswitchable diarylethenes: from molecular structures to biological applications
Z Li, X Zeng, C Gao, J Song, F He, T He, H Guo… - Coordination Chemistry …, 2023 - Elsevier
Diarylethene (DAE) photoswitches, known for their reversible photoinduced cyclization and
cycloreversion reactions, have shown great promise in various fields such as optical data …
cycloreversion reactions, have shown great promise in various fields such as optical data …
Emerging targets in photopharmacology
MM Lerch, MJ Hansen, GM van Dam… - Angewandte Chemie …, 2016 - Wiley Online Library
The field of photopharmacology uses molecular photoswitches to establish control over the
action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of …
action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of …
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
[HTML][HTML] The biological activities of butyrylcholinesterase inhibitors
S Zhou, G Huang - Biomedicine & pharmacotherapy, 2022 - Elsevier
Acetylcholinesterase (AChE) inhibitor is the first choice for the treatment of Alzheimer's
disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term …
disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term …
The molecular mechanism, targets, and novel molecules in the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurological illness that causes dementia mainly
in the elderly. The challenging obstacles related to AD has freaked global healthcare system …
in the elderly. The challenging obstacles related to AD has freaked global healthcare system …
A comprehensive review of cholinesterase modeling and simulation
D De Boer, N Nguyen, J Mao, J Moore, EJ Sorin - Biomolecules, 2021 - mdpi.com
The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …
butyrylcholinesterase structure and function using computer-based modeling and simulation …
Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition in Vitro and Enable Restoration of Cognition in an Alzheimer's …
M Scheiner, A Sink, M Hoffmann… - Journal of the …, 2022 - ACS Publications
To develop tools to investigate the biological functions of butyrylcholinesterase (BChE) and
the mechanisms by which BChE affects Alzheimer's disease (AD), we synthesized several …
the mechanisms by which BChE affects Alzheimer's disease (AD), we synthesized several …
Sign inversion in photopharmacology: Incorporation of cyclic azobenzenes in photoswitchable potassium channel blockers and openers
JB Trads, K Hüll, BS Matsuura, L Laprell… - Angewandte Chemie …, 2019 - Wiley Online Library
Photopharmacology relies on ligands that change their pharmacodynamics upon
photoisomerization. Many of these ligands are azobenzenes that are thermodynamically …
photoisomerization. Many of these ligands are azobenzenes that are thermodynamically …
Dual-acting small molecules: subtype-selective cannabinoid receptor 2 agonist/butyrylcholinesterase inhibitor hybrids show neuroprotection in an Alzheimer's disease …
P Spatz, SAM Steinmüller, A Tutov… - Journal of Medicinal …, 2023 - ACS Publications
We present the synthesis and characterization of merged human butyrylcholinesterase (h
BChE) inhibitor/cannabinoid receptor 2 (h CB2R) ligands for the treatment of …
BChE) inhibitor/cannabinoid receptor 2 (h CB2R) ligands for the treatment of …
Taking Photochromism beyond Visible: Direct One‐Photon NIR Photoswitches Operating in the Biological Window
K Klaue, Y Garmshausen… - Angewandte Chemie …, 2018 - Wiley Online Library
The success of photopharmacology is inevitably tied to the availability of photoswitches,
which can be operated within the biological window (λ= 650–1450 nm) to maximize …
which can be operated within the biological window (λ= 650–1450 nm) to maximize …