Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond
Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …
globe. Candida species are among the most common causes of invasive mycotic disease …
Post-translational modifications of Hsp90 and translating the chaperone code
SJ Backe, RA Sager, MR Woodford… - Journal of Biological …, 2020 - ASBMB
Cells have a remarkable ability to synthesize large amounts of protein in a very short period
of time. Under these conditions, many hydrophobic surfaces on proteins may be transiently …
of time. Under these conditions, many hydrophobic surfaces on proteins may be transiently …
Mechanisms of antifungal drug resistance
LE Cowen, D Sanglard… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Antifungal therapy is a central component of patient management for acute and chronic
mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal …
mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal …
Candidiasis: From cutaneous to systemic, new perspectives of potential targets and therapeutic strategies
H Lu, T Hong, Y Jiang, M Whiteway, S Zhang - Advanced Drug Delivery …, 2023 - Elsevier
Candidiasis is an infection caused by fungi from a Candida species, most commonly
Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on …
Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on …
Antifungal drugs: the current armamentarium and development of new agents
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
Combinatorial strategies for combating invasive fungal infections
Invasive fungal infections are an important cause of human mortality and morbidity,
particularly for immunocompromised populations. However, there remains a paucity of …
particularly for immunocompromised populations. However, there remains a paucity of …
[HTML][HTML] Drug resistance and novel therapeutic approaches in invasive candidiasis
SE Murphy, T Bicanic - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Candida species are the leading cause of invasive fungal infections worldwide and are
associated with acute mortality rates of~ 50%. Mortality rates are further augmented in the …
associated with acute mortality rates of~ 50%. Mortality rates are further augmented in the …
Molecular mechanisms governing antifungal drug resistance
Fungal pathogens are a severe public health problem. The leading causative agents of
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …
[PDF][PDF] The role of Candida albicans stress response pathways in antifungal tolerance and resistance
Human fungal pathogens are the causative agents of devastating diseases across the
globe, and the increasing prevalence of drug resistance threatens to undermine the already …
globe, and the increasing prevalence of drug resistance threatens to undermine the already …
Regulatory roles of histone modifications in filamentous fungal pathogens
Y Lai, L Wang, W Zheng, S Wang - Journal of Fungi, 2022 - mdpi.com
Filamentous fungal pathogens have evolved diverse strategies to infect a variety of hosts
including plants and insects. The dynamic infection process requires rapid and fine-tuning …
including plants and insects. The dynamic infection process requires rapid and fine-tuning …