Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Y Lee, E Puumala, N Robbins, LE Cowen - Chemical reviews, 2020 - ACS Publications
Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …

Post-translational modifications of Hsp90 and translating the chaperone code

SJ Backe, RA Sager, MR Woodford… - Journal of Biological …, 2020 - ASBMB
Cells have a remarkable ability to synthesize large amounts of protein in a very short period
of time. Under these conditions, many hydrophobic surfaces on proteins may be transiently …

Mechanisms of antifungal drug resistance

LE Cowen, D Sanglard… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Antifungal therapy is a central component of patient management for acute and chronic
mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal …

Candidiasis: From cutaneous to systemic, new perspectives of potential targets and therapeutic strategies

H Lu, T Hong, Y Jiang, M Whiteway, S Zhang - Advanced Drug Delivery …, 2023 - Elsevier
Candidiasis is an infection caused by fungi from a Candida species, most commonly
Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on …

Antifungal drugs: the current armamentarium and development of new agents

N Robbins, GD Wright, LE Cowen - Microbiology spectrum, 2016 - Am Soc Microbiol
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …

Combinatorial strategies for combating invasive fungal infections

M Spitzer, N Robbins, GD Wright - Virulence, 2017 - Taylor & Francis
Invasive fungal infections are an important cause of human mortality and morbidity,
particularly for immunocompromised populations. However, there remains a paucity of …

[HTML][HTML] Drug resistance and novel therapeutic approaches in invasive candidiasis

SE Murphy, T Bicanic - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Candida species are the leading cause of invasive fungal infections worldwide and are
associated with acute mortality rates of~ 50%. Mortality rates are further augmented in the …

Molecular mechanisms governing antifungal drug resistance

Y Lee, N Robbins, LE Cowen - npj Antimicrobials and Resistance, 2023 - nature.com
Fungal pathogens are a severe public health problem. The leading causative agents of
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …

[PDF][PDF] The role of Candida albicans stress response pathways in antifungal tolerance and resistance

KR Iyer, N Robbins, LE Cowen - Iscience, 2022 - cell.com
Human fungal pathogens are the causative agents of devastating diseases across the
globe, and the increasing prevalence of drug resistance threatens to undermine the already …

Regulatory roles of histone modifications in filamentous fungal pathogens

Y Lai, L Wang, W Zheng, S Wang - Journal of Fungi, 2022 - mdpi.com
Filamentous fungal pathogens have evolved diverse strategies to infect a variety of hosts
including plants and insects. The dynamic infection process requires rapid and fine-tuning …