Primary and metastatic peritoneal surface malignancies

D Cortes-Guiral, M Hübner, M Alyami, A Bhatt… - Nature Reviews …, 2021 - nature.com
Peritoneal surface malignancies comprise a heterogeneous group of primary tumours,
including peritoneal mesothelioma, and peritoneal metastases of other tumours, including …

mRNA vaccine era—mechanisms, drug platform and clinical prospection

S Xu, K Yang, R Li, L Zhang - International journal of molecular sciences, 2020 - mdpi.com
Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …

The effect of electrostatic high pressure nebulization on the stability, activity and ex vivo distribution of ionic self-assembled nanomedicines

H Braet, V Andretto, R Mariën, B Yücesan… - Acta Biomaterialia, 2023 - Elsevier
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is applied to treat unresectable
peritoneal metastasis (PM), an advanced, end-stage disease with a poor prognosis …

Overcoming drug resistance by taking advantage of physical principles: pressurized intraperitoneal aerosol chemotherapy (PIPAC)

G Nadiradze, P Horvath, Y Sautkin, R Archid… - Cancers, 2019 - mdpi.com
Theoretical considerations as well as comprehensive preclinical and clinical data suggest
that optimizing physical parameters of intraperitoneal drug delivery might help to circumvent …

Intraperitoneal aerosolized drug delivery: technology, recent developments, and future outlook

M Rahimi-Gorji, L Van de Sande, C Debbaut… - Advanced Drug Delivery …, 2020 - Elsevier
Current therapies for patients with peritoneal metastases (PM) are only moderately effective.
Recently, a novel locoregional treatment method for PM was introduced, consisting of a …

Synergy between intraperitoneal aerosolization (PIPAC) and cancer nanomedicine: cisplatin-loaded polyarginine-hyaluronic acid nanocarriers efficiently eradicate …

M Shariati, G Lollo, K Matha, B Descamps… - … applied materials & …, 2020 - ACS Publications
Intra-abdominal dissemination of peritoneal nodules, a condition known as peritoneal
carcinomatosis (PC), is typically diagnosed in ovarian cancer patients at the advanced …

Exploring high pressure nebulization of Pluronic F127 hydrogels for intraperitoneal drug delivery

H Braet, M Rahimi-Gorji, C Debbaut… - European Journal of …, 2021 - Elsevier
Peritoneal metastasis is an advanced cancer type which can be treated with pressurized
intraperitoneal aerosol chemotherapy (PIPAC). Here, chemotherapeutics are nebulized …

Electrostatic intraperitoneal aerosol delivery of nanoparticles: proof of concept and preclinical validation

L Van de Sande, M Rahimi‐Gorji… - Advanced …, 2020 - Wiley Online Library
There is an increasing interest in intraperitoneal delivery of chemotherapy as an aerosol in
patients with peritoneal metastasis. The currently used technology is hampered by …

Fluorescence‐based quantification of messenger RNA and plasmid DNA decay kinetics in extracellular biological fluids and cell extracts

H Zhang, K Rombouts, L Raes, R Xiong… - Advanced …, 2020 - Wiley Online Library
Extracellular and intracellular degradation of nucleic acids remains an issue in non‐viral
gene therapy. Understanding biodegradation is critical for the rational design of gene …

Fluorescence Correlation Spectroscopy to find the critical balance between extracellular association and intracellular dissociation of mRNA complexes

H Zhang, SC De Smedt, K Remaut - Acta biomaterialia, 2018 - Elsevier
Abstract Fluorescence Correlation Spectroscopy (FCS) is a promising tool to study
interactions on a single molecule level. The diffusion of fluorescent molecules in and out of …