Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …

Exosomes are nanovesicles with a wide range of chemical compositions used in many
different applications. Mesenchymal stem cell-derived exosomes (MSCs-EXOs) are …

Traumatic brain injury (TBI) leads to lasting brain dysfunction with chronic
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …

Reprogramming brain-resident glial cells into clinically relevant induced neurons (iNs) is an
emerging strategy toward replacing lost neurons and restoring lost brain functions. A …

Extracellular vesicles (EVs) derived from human bone marrow mesenchymal stem cells
(hMSCs) have great promise as biologics to treat neurological and neurodegenerative …

Temporal lobe epilepsy (TLE) is a common drug-resistant epilepsy associated with
abundant cell death in the hippocampus. Here, we develop a novel gene therapy-mediated …

Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of
patients have drug-refractory seizures and are left with suboptimal therapeutic options such …

Background: Despite the wide availability of novel anti-seizure medications (ASMs), 30% of
patients with epilepsy retain persistent seizures with a significant burden in comorbidity and …

Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …

Understanding how neurons of the striatum are formed and integrate into complex synaptic
circuits is essential to provide insight into striatal function in health and disease. In this …