Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation
DM Lonard, BW O'malley - Molecular cell, 2007 - cell.com
In a little more than 10 years, nuclear receptor (NR) coregulators (coactivators and
corepressors) have contributed to our present realization that a great level of sophistication …
corepressors) have contributed to our present realization that a great level of sophistication …
Born to bind: the BTB protein–protein interaction domain
R Perez‐Torrado, D Yamada, PA Defossez - Bioessays, 2006 - Wiley Online Library
The BTB domain is a protein–protein interaction motif that is found throughout eukaryotes. It
determines a unique tri‐dimensional fold with a large interaction surface. The exposed …
determines a unique tri‐dimensional fold with a large interaction surface. The exposed …
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
Disruption of the circadian clock exacerbates metabolic diseases, including obesity and
diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays …
diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays …
Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor
Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing
deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and …
deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and …
Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism
AL Hunter, CE Pelekanou… - Proceedings of the …, 2020 - National Acad Sciences
The nuclear receptor REVERBα is a core component of the circadian clock and proposed to
be a dominant regulator of hepatic lipid metabolism. Using antibody-independent ChIP …
be a dominant regulator of hepatic lipid metabolism. Using antibody-independent ChIP …
TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy
Background Classical NF-κB signaling functions as a negative regulator of skeletal
myogenesis through potentially multiple mechanisms. The inhibitory actions of TNFα on …
myogenesis through potentially multiple mechanisms. The inhibitory actions of TNFα on …
The role of HDAC3 in inflammation: mechanisms and therapeutic implications
N Watson, S Kuppuswamy, WL Ledford… - Frontiers in …, 2024 - frontiersin.org
Histone deacetylases (HDACs) are critical regulators of inflammatory gene expression, and
the efficacy of pan-HDAC inhibitors has been implicated in various disease conditions …
the efficacy of pan-HDAC inhibitors has been implicated in various disease conditions …
Identification of molecular mechanisms related to nonthyroidal illness syndrome in skeletal muscle and adipose tissue from patients with septic shock
A Rodriguez‐Perez, F Palos‐Paz… - Clinical …, 2008 - Wiley Online Library
Objective Septic shock is one of various causes of nonthyroidal illness syndrome (NTIS). In
humans, the molecular mechanisms involved in NTIS are mostly unknown. The aim of this …
humans, the molecular mechanisms involved in NTIS are mostly unknown. The aim of this …
30 years of the mineralocorticoid receptor: coregulators as mediators of mineralocorticoid receptor signalling diversity
The cloning of the mineralocorticoid receptor (MR) 30 years ago was the start of a new era of
research into the regulatory processes of MR signalling at target genes in the distal nephron …
research into the regulatory processes of MR signalling at target genes in the distal nephron …
The actions of thyroid hormone signaling in the nucleus
KR Vella, AN Hollenberg - Molecular and cellular endocrinology, 2017 - Elsevier
Thyroid hormones are a critical regulator of mammalian physiology. Much of their action is
due to effects in the nucleus where T 3 engages thyroid hormone receptor isoforms to …
due to effects in the nucleus where T 3 engages thyroid hormone receptor isoforms to …