[HTML][HTML] Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application
H Gao, J Yin, C Ji, X Yu, J Xue, X Guan… - Journal of Experimental …, 2023 - Springer
Tumors have evolved in various mechanisms to evade the immune system, hindering the
antitumor immune response and facilitating tumor progression. Immunotherapy has become …
antitumor immune response and facilitating tumor progression. Immunotherapy has become …
[HTML][HTML] Multiple functions of USP18
N Honke, N Shaabani, DE Zhang, C Hardt… - Cell death & …, 2016 - nature.com
Since the discovery of the ubiquitin system and the description of its important role in the
degradation of proteins, many studies have shown the importance of ubiquitin-specific …
degradation of proteins, many studies have shown the importance of ubiquitin-specific …
[HTML][HTML] The diverse repertoire of ISG15: More intricate than initially thought
JA Kang, YJ Kim, YJ Jeon - Experimental & Molecular Medicine, 2022 - nature.com
ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like
protein (UBL), which plays multifaceted roles not only as a free intracellular or extracellular …
protein (UBL), which plays multifaceted roles not only as a free intracellular or extracellular …
ISG15 in cancer: Beyond ubiquitin-like protein
HG Han, HW Moon, YJ Jeon - Cancer letters, 2018 - Elsevier
ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like
protein (Ubl), playing roles not only as an unconjugated form but also as a covalently …
protein (Ubl), playing roles not only as an unconjugated form but also as a covalently …
USP18–a multifunctional component in the interferon response
Ubiquitin-specific proteases (USPs) represent the largest family of deubiquitinating enzymes
(DUB). These proteases cleave the isopeptide bond between ubiquitin and a lysine residue …
(DUB). These proteases cleave the isopeptide bond between ubiquitin and a lysine residue …
[HTML][HTML] Identification of key interferon-stimulated genes for indicating the condition of patients with systemic lupus erythematosus
M Shen, C Duan, C Xie, H Wang, Z Li, B Li… - Frontiers in …, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with highly
heterogeneous clinical symptoms and severity. There is complex pathogenesis of SLE, one …
heterogeneous clinical symptoms and severity. There is complex pathogenesis of SLE, one …
[HTML][HTML] Emerging roles of USP18: From biology to pathophysiology
JA Kang, YJ Jeon - International journal of molecular sciences, 2020 - mdpi.com
Eukaryotic proteomes are enormously sophisticated through versatile post-translational
modifications (PTMs) of proteins. A large variety of code generated via PTMs of proteins by …
modifications (PTMs) of proteins. A large variety of code generated via PTMs of proteins by …
Paradoxical suppression of atherosclerosis in the absence of microRNA-146a
Rationale: Inflammation is a key contributor to atherosclerosis. MicroRNA-146a (miR-146a)
has been identified as a critical brake on proinflammatory nuclear factor κ light chain …
has been identified as a critical brake on proinflammatory nuclear factor κ light chain …
[HTML][HTML] Macrophage phenotypes and hepatitis B virus infection
Y Li, S Li, X Duan, C Yang, M Xu… - Journal of Clinical and …, 2020 - ncbi.nlm.nih.gov
Globally, hepatitis B virus (HBV) infection and its related liver diseases account for 780,000
deaths every year. Outcomes of HBV infection depend on the interaction between the virus …
deaths every year. Outcomes of HBV infection depend on the interaction between the virus …
Antiviral activity of bone morphogenetic proteins and activins
LA Eddowes, K Al-Hourani, N Ramamurthy… - Nature …, 2019 - nature.com
Understanding the control of viral infections is of broad importance. Chronic hepatitis C virus
(HCV) infection causes decreased expression of the iron hormone hepcidin, which is …
(HCV) infection causes decreased expression of the iron hormone hepcidin, which is …