Tumors have evolved in various mechanisms to evade the immune system, hindering the
antitumor immune response and facilitating tumor progression. Immunotherapy has become …

Since the discovery of the ubiquitin system and the description of its important role in the
degradation of proteins, many studies have shown the importance of ubiquitin-specific …

ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like
protein (UBL), which plays multifaceted roles not only as a free intracellular or extracellular …

ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like
protein (Ubl), playing roles not only as an unconjugated form but also as a covalently …

Ubiquitin-specific proteases (USPs) represent the largest family of deubiquitinating enzymes
(DUB). These proteases cleave the isopeptide bond between ubiquitin and a lysine residue …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with highly
heterogeneous clinical symptoms and severity. There is complex pathogenesis of SLE, one …

Eukaryotic proteomes are enormously sophisticated through versatile post-translational
modifications (PTMs) of proteins. A large variety of code generated via PTMs of proteins by …

Rationale: Inflammation is a key contributor to atherosclerosis. MicroRNA-146a (miR-146a)
has been identified as a critical brake on proinflammatory nuclear factor κ light chain …

Globally, hepatitis B virus (HBV) infection and its related liver diseases account for 780,000
deaths every year. Outcomes of HBV infection depend on the interaction between the virus …

Understanding the control of viral infections is of broad importance. Chronic hepatitis C virus
(HCV) infection causes decreased expression of the iron hormone hepcidin, which is …