Dendritic cells (DCs) are essential in immunity owing to their role in activating T cells,
thereby promoting antitumor responses. Tumor cells, however, hijack the immune system …

Antigen-presenting dendritic cells often acquire foreign antigens in peripheral tissues such
as the skin. Optimal encounter with naive T cells for the presentation of these antigens …

Dendritic cells play a key role in processing and presenting antigens to naïve T cells to
prime adaptive immunity. Circadian rhythms are known to regulate many aspects of …

Pediatric-onset colitis and inflammatory bowel disease (IBD) have significant effects on the
growth of infants and children, but the etiopathogenesis underlying disease subtypes …

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of
migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of …

Immunosuppressive drugs have revolutionized organ transplantation and improved the
therapeutic management of autoimmune diseases. The development of immunosuppressive …

The ability of dendritic cells (DCs) to initiate and orchestrate immune responses is a
consequence of their localization within tissues and their specialized capacity for …

Chemokines are pivotal regulators of cell migration during continuous immune surveillance,
inflammation, homeostasis, and development. Chemokine binding to their 7-transmembrane …

Many members of the chemokine receptor family of G protein-coupled receptors utilize
multiple endogenous ligands. However, differences between the signaling properties of …

A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here
we summarize recent findings on the initial steps in chemokine receptor–induced signal …