Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark
pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary …

Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral …

The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but
neurons do not work in isolation. Emerging evidence suggests that the intricate balance of …

The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …

Introduction We investigated plasma proteomic markers of astrocytopathy, brain
degeneration, plasticity, and inflammation in sporadic early-onset versus late-onset …

Introduction White matter hyperintensities (WMH) are often described in Alzheimer's disease
(AD), but their topography and specific relationships with cognition remain unclear. Methods …

Cerebral white matter lesions (WML) encompass axonal loss and demyelination and are
assumed to be associated with small vessel disease (SVD)-related ischaemia. However, our …

Background and Objectives Topographical distribution of white matter hyperintensities
(WMH) are hypothesized to vary by cerebrovascular risk factors. We used an unbiased …

Neurofilament light (NfL) is a marker of neuroaxonal injury, a prominent feature of
Alzheimer's disease. It remains uncertain, however, how it relates to amyloid and tau …