This perspective is partly review and partly proposal. N-degrons and C-degrons are
degradation signals whose main determinants are, respectively, the N-terminal and C …

Cancer is a global issue majorly affecting developing countries. According to a survey, 63%
of deaths due to cancer are reported from developing countries. There are different …

Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in
ovarian cancer (OC) facilitate tumor growth and progression, and also pose major obstacles …

Ubiquitin (Ub) chain formation by homologous to E6AP C-terminus (HECT)-family E3 ligases
regulates vast biology, yet the structural mechanisms remain unknown. We used chemistry …

UBR5 is a nuclear E3 ligase that ubiquitinates a vast range of substrates for proteasomal
degradation. This HECT domain‐containing ubiquitin ligase has recently been identified as …

Background: The up-regulation of PD-L1 is recognized as an adaption of cancer cells to
evade immune surveillance and attack. However, the intrinsic mechanisms of the induction …

Pancreatic cancer is one of the most fatal cancers in humans. While it thrives in a state of
malnutrition, the mechanism by which pancreatic cancer cells adapt to metabolic stress …

The human UBR5 is a single polypeptide chain homology to E6AP C terminus (HECT)-type
E3 ubiquitin ligase essential for embryonic development in mammals. Dysregulated UBR5 …

As a transcription factor critical for embryonic and adult stem cell self-renewal and function,
SOX2 gene amplification has been recognized as a driving factor for various cancers …

Patients with triple-negative breast cancers (TNBC) are at high risk for recurrence and
metastasis at an early time despite standard treatment, underscoring the need for novel …