Integrating immunology and microfluidics for single immune cell analysis
N Sinha, N Subedi, J Tel - Frontiers in immunology, 2018 - frontiersin.org
The field of immunoengineering aims to develop novel therapies and modern vaccines to
manipulate and modulate the immune system and applies innovative technologies toward …
manipulate and modulate the immune system and applies innovative technologies toward …
Quantitative mechanistic modeling in support of pharmacological therapeutics development in immuno-oncology
Following the approval, in recent years, of the first immune checkpoint inhibitor, there has
been an explosion in the development of immuno-modulating pharmacological modalities …
been an explosion in the development of immuno-modulating pharmacological modalities …
Endocrine autoimmune disease as a fragility of immune surveillance against hypersecreting mutants
Some endocrine organs are frequent targets of autoimmune attack. Here, we addressed the
origin of autoimmune disease from the viewpoint of feedback control. Endocrine tissues …
origin of autoimmune disease from the viewpoint of feedback control. Endocrine tissues …
[HTML][HTML] A dynamic model of immune responses to antigen presentation predicts different regions of tumor or pathogen elimination
ED Sontag - Cell Systems, 2017 - cell.com
The immune system must discriminate between agents of disease and an organism's
healthy cells. While the identification of an antigen as self/non-self is critically important, the …
healthy cells. While the identification of an antigen as self/non-self is critically important, the …
Mathematical modeling in autoimmune diseases: from theory to clinical application
The research & development (R&D) of novel therapeutic agents for the treatment of
autoimmune diseases is challenged by highly complex pathogenesis and multiple etiologies …
autoimmune diseases is challenged by highly complex pathogenesis and multiple etiologies …
Importance of feedback and feedforward loops to adaptive immune response modeling
The human adaptive immune system is a very complex network of different types of cells,
cytokines, and signaling molecules. This complex network makes it difficult to understand …
cytokines, and signaling molecules. This complex network makes it difficult to understand …
A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease
A Yazdani, F Bahrami, A Pourgholaminejad… - Theory in …, 2023 - Springer
In this study, we proposed a biological model explaining the progress of autoimmune
activation along different stages of systemic lupus erythematosus (SLE). For any upcoming …
activation along different stages of systemic lupus erythematosus (SLE). For any upcoming …
A signal integration model of thymic selection and natural regulatory T cell commitment
S Khailaie, PA Robert, A Toker, J Huehn… - The Journal of …, 2014 - journals.aai.org
The extent of TCR self-reactivity is the basis for selection of a functional and self-tolerant T
cell repertoire and is quantified by repeated engagement of TCRs with a diverse pool of self …
cell repertoire and is quantified by repeated engagement of TCRs with a diverse pool of self …
Third-kind encounters in biomedicine: immunology meets mathematics and informatics to become quantitative and predictive
The understanding of the immune response is right now at the center of biomedical
research. There are growing expectations that immune-based interventions will in the …
research. There are growing expectations that immune-based interventions will in the …
Stochastic modeling of tumor progression and immune evasion
It is now well-established that the host's adaptive immune system plays an important role in
identifying and eliminating cancer cells in much the same way that intracellular pathogens …
identifying and eliminating cancer cells in much the same way that intracellular pathogens …