The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

Cumulative evidence suggests that impaired cerebrovascular reactivity (CVR), a regulatory
response critical for maintaining neuronal health, is amongst the earliest pathological …

Transcranial Doppler ultrasonography (TCD) is a noninvasive, portable, bedside tool for
assessment of cerebral hemodynamics (Box 1). The instrument displays spectral waveforms …

Cerebrovascular dysfunction has been suggested as a physiomarker of Alzheimer's disease
(AD)-associated neuronal degeneration, but the underlying mechanisms are still debated …

Alzheimer's disease (AD) is the commonest cause of dementia. There are tremendous
personal and systemic costs associated with the disease. Although there has been …

Abstract Introduction: Transcranial Doppler (TCD) sonography is a noninvasive tool for
measuring cerebrovascular hemodynamics. Studies have reported alterations in …

Background: Cerebrovascular hemodynamic impairment has been reported in Alzheimer's
disease (AD). We performed a systematic review and meta-analysis to investigate changes …

Background and Purpose: Alzheimer's disease and related dementias (ADRD)
disproportionately affect minorities and socially disadvantaged groups. To add to our current …

Normal aging leads to endothelial dysfunction and arterial stiffening implicated in cognitive
decline. Cerebral blood flow also declines with aging. Elevated blood flow during exercise …