Caged compounds are light-sensitive probes that functionally encapsulate biomolecules in
an inactive form. Irradiation liberates the trapped molecule, permitting targeted perturbation …

Biologically active compounds which are light‐responsive offer experimental possibilities
which are otherwise very difficult to achieve. Since light can be manipulated very precisely …

The earliest step in creating the cerebral cortex is the specification of neuroepithelium to a
cortical fate. Using mouse genetic mosaics and timed inactivations, we demonstrated that …

In the vertebrate olfactory system, odor information is represented as a topographic map in
the olfactory bulb (OB). However, it remains unknown how this odor map is transferred from …

Müller glia are the resident radial glia in the vertebrate retina. The response of mammalian
Müller glia to retinal damage often results in a glial scar and no functional replacement of …

Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder, associated with
a variable clinical phenotype including café-au-lait spots, intertriginous freckling, Lisch …

Biologisch aktive Verbindungen, die auf Licht reagieren, bieten experimentelle
Möglichkeiten, die sonst nur sehr schwierig zu realisieren sind. Da Licht z. B. mit Lasern und …

Pilocytic astrocytomas (PAs) are the most common glioma in children. Whereas many PAs
are slow-growing or clinically indolent, others exhibit more aggressive features with tumor …

Within the past years RNA interference (RNAi) has become one of the most valuable tools
for post-transcriptional gene silencing. Making RNAi temporally and/or spatially controllable …

Initial axial patterning of the neural tube into forebrain, midbrain, and hindbrain primordia
occurs during gastrulation. After this patterning phase, further diversification within the brain …