2018 marks the 100-year anniversary of the 1918 influenza pandemic, which killed~ 50
million people worldwide. The severity of this pandemic resulted from a complex interplay …

Memory T cells constitute the most abundant lymphocyte population in the body for the
majority of a person's lifetime; however, our understanding of memory T cell generation …

The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines and therapeutics will depend on understanding viral immunity. We studied T cell …

The role of T cells in mediating heterosubtypic protection against natural influenza illness in
humans is uncertain. The 2009 H1N1 pandemic (pH1N1) provided a unique natural …

One of the most appreciated consequences of immunosenescence is an impaired response
to vaccines with advanced age. While most studies report impaired antibody responses in …

Protective immunity against influenza virus infection is mediated by neutralizing antibodies,
but the precise role of T cells in human influenza immunity is uncertain. We conducted …

The challenges in successful vaccination against influenza using conventional approaches
lie in their variable efficacy in different age populations, the antigenic variability of the …

The extent to which tissue-specific viral infections generate memory T cells specifically
adapted to and maintained within the target infection site is unknown. Here, we show that …

Influenza viruses cause annual outbreaks of respiratory tract infection with attack rates of 5–
10%. This means that humans are infected repeatedly with intervals of, on average, 10–20 …

Influenza A and B virus infections are a major cause of respiratory disease in humans and
are responsible for substantial morbidity and mortality worldwide. Vaccination against …