Alteration in the composition of the gut microbiota can lead to a number of chronic clinical
diseases. Akkermansia muciniphila is an anaerobic bacteria constituting 3–5% of the gut …

Due to its safety, convenience, low cost and good compliance, oral administration attracts
lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory …

The development of a single immuno-metabolic adjuvant capable of modulating, in the
appropriate direction and intensity, the complex antagonistic and symbiotic interplays …

The identification of new probiotics with anti-obesity properties has attracted considerable
interest. In the present study, the anti-obesity activities of Akkermansia muciniphila (A …

Osteoarthritis (OA) is the most common form of arthritis and age-related degenerative joint
disorder, which adversely affects quality of life and causes disability. However, the …

Ethnopharmacological relevance The global problem of diabetes, together with the limited
access of large numbers of patients to conventional antidiabetic medicines, continues to …

Introduction Many clinical studies have proved the effectiveness of probiotics in metabolic
disorders associated with insulin resistance. However, the impact of probiotic therapy on …

An imbalance in the crosstalk between the host and gut microbiota affects the intestinal
barrier function, which results in inflammatory diseases and colorectal cancer. The colon …

The intestinal microbiota plays an important role in maintaining human health, and its
alteration is now associated with the development of various gastrointestinal (ulcerative …

Objective Recent studies have demonstrated that gut microbiota was closely related to
metabolic disorders such as type 2 diabetes. Oral antidiabetic medications including …