[HTML][HTML] Insoluble drug delivery strategies: review of recent advances and business prospects
S Kalepu, V Nekkanti - Acta Pharmaceutica Sinica B, 2015 - Elsevier
The emerging trends in the combinatorial chemistry and drug design have led to the
development of drug candidates with greater lipophilicity, high molecular weight and poor …
development of drug candidates with greater lipophilicity, high molecular weight and poor …
Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Role of nanoparticle size, shape and surface chemistry in oral drug delivery
A Banerjee, J Qi, R Gogoi, J Wong… - Journal of Controlled …, 2016 - Elsevier
Nanoparticles find intriguing applications in oral drug delivery since they present a large
surface area for interactions with the gastrointestinal tract and can be modified in various …
surface area for interactions with the gastrointestinal tract and can be modified in various …
50 years of oral lipid-based formulations: provenance, progress and future perspectives
Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …
Review and analysis of FDA approved drugs using lipid-based formulations
R Savla, J Browne, V Plassat, KM Wasan… - Drug development and …, 2017 - Taylor & Francis
Lipid-based drug delivery systems (LBDDS) are one of the most studied bioavailability
enhancement technologies and are utilized in a number of US Food and Drug …
enhancement technologies and are utilized in a number of US Food and Drug …
[HTML][HTML] Raman spectroscopy in pharmaceutical product design
Almost 100 years after the discovery of the Raman scattering phenomenon, related
analytical techniques have emerged as important tools in biomedical sciences. Raman …
analytical techniques have emerged as important tools in biomedical sciences. Raman …
Lipid based nanocarriers: a translational perspective
Over the recent couple of decades, pharmaceutical field has embarked most phenomenal
noteworthy achievements in the field of medications as well as drug delivery. The rise of …
noteworthy achievements in the field of medications as well as drug delivery. The rise of …
Bioavailability enhancement of poorly water-soluble drugs via nanocomposites: Formulation–Processing aspects and challenges
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, ie, drug-laden
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …
Self-microemulsifying drug delivery system (SMEDDS)–challenges and road ahead
S Dokania, AK Joshi - Drug delivery, 2015 - Taylor & Francis
Self-microemulsifying drug delivery system (SMEDDS) has emerged as a vital strategy to
formulate poor water soluble compounds for bioavailability enhancement. However, certain …
formulate poor water soluble compounds for bioavailability enhancement. However, certain …
Lipid-based formulations for oral administration of poorly water-soluble drugs
Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly
water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed …
water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed …