The many alternative faces of macrophage activation

DA Hume - Frontiers in immunology, 2015 - frontiersin.org
Monocytes and macrophages provide the first line of defense against pathogens. They also
initiate acquired immunity by processing and presenting antigens and provide the …

Endotoxin signal transduction in macrophages

MJ Sweet, DA Hume - Journal of leukocyte biology, 1996 - academic.oup.com
Through its action on macrophages, bacterial lipopolysaccharide (LPS) or endotoxin can
trigger responses that are protective or injurious to the host. This review examines the effects …

Regulation of B lymphocyte and macrophage development by graded expression of PU. 1

RP DeKoter, H Singh - Science, 2000 - science.org
The ets family transcription factor PU. 1 is required for the development of multiple lineages
of the immune system. Using retroviral transduction of PU. 1 complementary DNA into …

Transcription factors, normal myeloid development, and leukemia

DG Tenen, R Hromas, JD Licht… - Blood, The Journal of …, 1997 - ashpublications.org
Our understanding of myeloid factors has been brought about we will focus on how
alteration of myeloid transcription by a number of different methods. Initially, myeloid factors …

Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues

SM Millard, O Heng, KS Opperman, A Sehgal… - Cell reports, 2021 - cell.com
Mouse hematopoietic tissues contain abundant tissue-resident macrophages that support
immunity, hematopoiesis, and bone homeostasis. A systematic strategy to characterize …

A transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system

K Grabert, A Sehgal, KM Irvine… - The Journal of …, 2020 - journals.aai.org
The proliferation, differentiation, and survival of cells of the mononuclear phagocyte system
(MPS; progenitors, monocytes, macrophages, and classical dendritic cells) are controlled by …

Basic mechanisms of transcript elongation and its regulation

SM Uptain, CM Kane… - Annual review of …, 1997 - annualreviews.org
Ternary complexes of DNA-dependent RNA polymerase with its DNA template and nascent
transcript are central intermediates in transcription. In recent years, several unusual …

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

BS Yang, CA Hauser, G Henkel… - … and cellular biology, 1996 - Am Soc Microbiol
The Ras oncogene products regulate the expression of genes in transformed cells, and
members of the Ets family of transcription factors have been implicated in this process. To …

Expression and function of Ets transcription factors in mammalian development: a regulatory network

IG Maroulakou, DB Bowe - Oncogene, 2000 - nature.com
The Ets transcription factor family is involved in a variety of mammalian developmental
processes at the cellular, tissue and organ levels. They are implicated in cellular …

[PDF][PDF] Structure, function, and regulation of tartrate-resistant acid phosphatase

GW Oddie, G Schenk, NZ Angel, N Walsh, LW Guddat… - Bone, 2000 - eprints.nuim.ie
The tartrate-resistant acid phosphatases (TRAPs) are a class of metalloenzymes that
catalyze the hydrolysis of various phosphate esters and anhydrides under acidic reaction …