Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic
and adult structures, and disruption of Hh signaling pathways results in various human …

The central component in the road trip of axon guidance is the growth cone, a dynamic
structure that is located at the tip of the growing axon. During its journey, the growth cone …

Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin
cytoskeleton. Cells modify focal adhesions in response to changes in the molecular …

Regulation of cell growth and proliferation has a fundamental role in animal and plant
development and in the progression of cancer. In the context of development, it is important …

Cell migration plays a critical role in a wide variety of physiological and pathological
phenomena as well as in scaffold-based tissue engineering. Cell migration behavior is …

Directed cell migration is a complex process that involves front–rear polarization,
characterized by cell adhesion and cytoskeleton-based protrusion, retraction, and …

Sonic hedgehog (Shh) plays essential roles in developmental events such as cell fate
specification and axon guidance. Shh induces cell fate specification through canonical Shh …

Migrating cells extend protrusions, probing the surrounding matrix in search of permissive
sites to form adhesions. We found that actin fibers polymerizing along the leading edge …

Neurite outgrowth underlies the wiring of the nervous system during development and
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …