How tissues acquire complex shapes is a fundamental question in biology and regenerative
medicine. Zebrafish semicircular canals form from invaginations in the otic epithelium (buds) …

A key embryonic process that occurs early in ocular development is optic fissure closure
(OFC). This fusion process closes the ventral optic fissure and completes the circumferential …

Epithelial fusion underlies many vital organogenic processes during embryogenesis.
Disruptions to these cause a significant number of human birth defects, including ocular …

Epithelial remodelling plays a crucial role during development. The ability of epithelial
sheets to temporarily lose their integrity as they fuse with other epithelial sheets underpins …

During brainstem development, newborn neurons originating from the rhombic lip embark
on exceptionally long migrations to generate nuclei important for audition, movement, and …

Background Sensorineural hearing loss is an understudied consequence of congenital Zika
syndrome, and balance disorders are essentially unreported to date. Also lacking is …

During the development of the central nervous system (CNS), only motor axons project into
peripheral nerves. Little is known about the cellular and molecular mechanisms that control …

Previous genome-wide association study of nonsyndromic cleft lip with or without cleft palate
(NSCL/P) identified a susceptible variant (rs4791774). We hypothesized that the functional …

The semicircular canals of the mammalian inner ear are derived from epithelial pouches in
which epithelial cells in the central region of each pouch undergo resorption, leaving behind …

NTN1 is expressed in a wide range of developmental tissues and is essential for normal
development. Here we describe the generation of a Netrin-1 reporter chicken line (NTN1 …