Emerging connections between cerebellar development, behaviour and complex brain disorders

A Sathyanesan, J Zhou, J Scafidi, DH Heck… - Nature Reviews …, 2019 - nature.com
The human cerebellum has a protracted developmental timeline compared with the
neocortex, expanding the window of vulnerability to neurological disorders. As the …

From movement to thought: executive function, embodied cognition, and the cerebellum

LF Koziol, DE Budding, D Chidekel - The Cerebellum, 2012 - Springer
This paper posits that the brain evolved for the control of action rather than for the
development of cognition per se. We note that the terms commonly used to describe brain …

Spatial and cell type transcriptional landscape of human cerebellar development

KA Aldinger, Z Thomson, IG Phelps, P Haldipur… - Nature …, 2021 - nature.com
The human neonatal cerebellum is one-fourth of its adult size yet contains the blueprint
required to integrate environmental cues with developing motor, cognitive and emotional …

Cellular commitment in the developing cerebellum

H Marzban, MR Del Bigio, J Alizadeh… - Frontiers in cellular …, 2015 - frontiersin.org
The mammalian cerebellum is located in the posterior cranial fossa and is critical for motor
coordination and non-motor functions including cognitive and emotional processes. The …

Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum

P Haldipur, KA Aldinger, S Bernardo, M Deng… - Science, 2019 - science.org
We present histological and molecular analyses of the developing human cerebellum from
30 days after conception to 9 months after birth. Differences in developmental patterns …

Human cerebellar development and transcriptomics: implications for neurodevelopmental disorders

P Haldipur, KJ Millen, KA Aldinger - Annual review of …, 2022 - annualreviews.org
Developmental abnormalities of the cerebellum are among the most recognized structural
brain malformations in human prenatal imaging. Yet reliable information regarding their …

Developmental delay in moderately preterm-born children with low socioeconomic status: risks multiply

MR Potijk, JM Kerstjens, AF Bos, SA Reijneveld… - The Journal of …, 2013 - Elsevier
Objective To assess separate and joint effects of low socioeconomic status (SES) and
moderate prematurity on preschool developmental delay. Study design Prospective cohort …

[HTML][HTML] Unravelling the Cerebellar Involvement in Autism Spectrum Disorders: Insights into Genetic Mechanisms and Developmental Pathways

M Guerra, V Medici, G La Sala, D Farini - Cells, 2024 - mdpi.com
Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions
characterized by deficits in social interaction and communication, as well as repetitive …

Interactions between purkinje cells and granule cells coordinate the development of functional cerebellar circuits

ME van der Heijden, RV Sillitoe - Neuroscience, 2021 - Elsevier
Cerebellar development has a remarkably protracted morphogenetic timeline that is
coordinated by multiple cell types. Here, we discuss the intriguing cellular consequences of …

Brain volumes and cognitive function in very-low-birth-weight (VLBW) young adults

KJ Bjuland, LM Rimol, GCC Løhaugen… - European Journal of …, 2014 - Elsevier
Background Preterm born very-low-birth-weight (VLBW: birth weight≤ 1500 g) survivors
have increased risk of perinatal brain injury that may cause deviant brain development and …