Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

We previously reviewed the use of 19 F NMR in the broad field of chemical biology [Cobb,
SL; Murphy, CD J. Fluorine Chem. 2009, 130, 132–140] and present here a summary of the …

G-quadruplexes (G4s) are noncanonical nucleic acid secondary structures with diverse
topological features and biological roles. Human telomeric (Htelo) overhangs consisting of …

In the present study, we employed a 19F NMR approach to study the association of telomere
RNA and DNA in vitro and in living human cells. We successfully characterized the DNA …

Z-DNA is known to be a left-handed alternative form of DNA and has important biological
roles as well as being related to cancer and other genetic diseases. It is therefore important …

Recently, the 1H-detected in-cell NMR spectroscopy has emerged as a unique tool allowing
the characterization of interactions between nucleic acid-based targets and drug-like …

Summary DNA G-quadruplex (G4) is a non-canonical four-stranded secondary structure that
has been shown to play a role in epigenetic modulation of gene expression. Here, we …