Cancer is the main cause of death worldwide and metastasis is a major cause of poor
prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a …

Cancer is a complex illness that presents significant challenges in its understanding and
treatment. The classic definition," a group of diseases characterized by the uncontrolled …

For hundreds of years, the drug discovery and development industry has aimed at
identifying single components with a clear mechanism of action as desirable candidates for …

Drug targets are specific molecules in biological tissues and body fluids that interact with
drugs. Drug target discovery is a key component of drug discovery and is essential for the …

Head and neck squamous cell carcinomas (HNSCC) are associated with significant
treatment-related morbidity and poor disease-free and disease-specific survival, especially …

Despite, melatonin is mainly known as a regulatory factor for circadian rhythm, its notable
role in other fundamental biological processes, such as redox homeostasis and …

Coronaviruses (CoVs) have continuously posed a threat to human and animal health.
However, existing antiviral drugs are still insufficient in overcoming the challenges caused …

Clustered regularly interspaced short palindromic repeats (CRISPR) is a third-generation
genome editing method that has revolutionized the world with its high throughput results. It …

Triple negative breast cancer (TNBC) has been well-known to be closely associated with the
abnormal expression of both oncogenes and tumor suppressors. Although several …

Background and aims Sorafenib is a major nonsurgical option for patients with advanced
hepatocellular carcinoma (HCC); however, its clinical efficacy is largely undermined by the …