Dysfunction of the glymphatic system as a potential mechanism of perioperative neurocognitive disorders

X Ren, S Liu, C Lian, H Li, K Li, L Li… - Frontiers in Aging …, 2021 - frontiersin.org
Perioperative neurocognitive disorder (PND) frequently occurs in the elderly as a severe
postoperative complication and is characterized by a decline in cognitive function that …

The impact of surgery and anesthesia on post-operative cognitive decline and Alzheimer's disease development: biomarkers and preventive strategies

AK Kapila, HR Watts, T Wang… - Journal of Alzheimer's …, 2014 - content.iospress.com
Alzheimer's disease (AD) is a major social and clinical burden in the elderly, affecting 5% of
people aged over 65 and 20% aged over 80. Despite improved management, a cure has not …

Post-operative cognitive dysfunction in the elderly: A prospective clinical study

N Kotekar, CS Kuruvilla, V Murthy - Indian journal of anaesthesia, 2014 - journals.lww.com
Methods: This study was conducted on 200 patients aged 60 years or older scheduled for
elective non-cardiac surgeries. The baseline cognitive status of the patients was assessed 2 …

Effect of inhalational anaesthetic on postoperative cognitive dysfunction following radical rectal resection in elderly patients with mild cognitive impairment

N Tang, C Ou, Y Liu, Y Zuo… - Journal of international …, 2014 - journals.sagepub.com
Aims: To determine the effect of choice of inhalational anaesthetic (sevoflurane vs propofol)
on the incidence and severity of postoperative cognitive dysfunction (POCD) in elderly …

Anesthesia and cognitive disorders: a systematic review of the clinical evidence

F Bilotta, E Qeva, I Matot - Expert review of neurotherapeutics, 2016 - Taylor & Francis
Introduction: Preclinical and clinical evidence suggest an association between anesthesia
and cognitive disorders ranging from postoperative chronic dysfunction to Alzheimer's …

Biomarkers of brain damage and postoperative cognitive disorders in orthopedic patients: an update

D Tomaszewski - BioMed research international, 2015 - Wiley Online Library
The incidence of postoperative cognitive dysfunction (POCD) in orthopedic patients varies
from 16% to 45%, although it can be as high as 72%. As a consequence, the hospitalization …

Postoperative cognitive dysfunction in the elderly: a review comparing the effects of desflurane and sevflurane

R Alalawi, N Yasmeen - Journal of Perianesthesia Nursing, 2018 - Elsevier
Purpose The incidence of postoperative cognitive dysfunction (POCD) remains a relatively
common complication in the elderly following surgery. Use of anesthesia for surgery might …

Toxicity of inhaled agents after prolonged administration

P Manatpon, WA Kofke - Journal of clinical monitoring and computing, 2018 - Springer
Inhaled anesthetics have been utilized mostly for general anesthesia in the operating room
and oftentimes for sedation and for treatment of refractory status epilepticus and status …

Apoptosis inhibition is involved in improvement of sevoflurane‑induced cognitive impairment following normobaric hyperoxia preconditioning in aged rats

Y Wang, CP Yin, YL Tai, ZJ Zhao… - Experimental and …, 2021 - spandidos-publications.com
Sevoflurane, a commonly used anesthetic agent has been confirmed to induce cognitive
impairment in aged rats. Normobaric hyperoxia preconditioning has been demonstrated to …

The management of postoperative cognitive dysfunction in cirrhotic patients: an overview of the literature

DG Ingustu, B Pavel, SI Paltineanu, DI Mihai… - Medicina, 2023 - mdpi.com
Background and objectives: Postoperative cognitive dysfunction (POCD) represents a
decreased cognitive performance in patients undergoing general anesthesia for major …