We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Background Opioids are potent painkillers but come with serious adverse effects ranging
from addiction to potentially lethal respiratory depression. A variety of drugs with separate …

The ventilatory control system is highly vulnerable to exogenous administered opioid
analgesics. Particularly respiratory depression is a potentially lethal complication that may …

Background Opioids can produce life-threatening respiratory depression. This study tested
whether subanaesthetic doses of esketamine stimulate breathing in an established human …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease; survival in ALS is
typically 3–5 years. No treatment extends patient survival by more than three months …

Pompe disease (glycogen storage disease type II) is caused by mutations in acid α-
glucosidase (GAA) resulting in lysosomal pathology and impairment of the muscular and …

Incorporation of heterocycles into drug molecules can enhance physical properties and
biological activity. A variety of heterocyclic groups is available to medicinal chemists, many …

Respiratory depression is the proximal cause of death in opioid overdose, yet the
mechanisms underlying this potentially fatal outcome are not well understood. The goal of …

Spinal cord hemisection at C2 (C2SH), sparing the dorsal column is widely used to
investigate the effects of reduced phrenic motor neuron (PhMN) activation on diaphragm …

Respiratory compromise after cervical spinal cord injury (SCI) is a leading cause of mortality
and morbidity. Most SCIs are incomplete, and spinal respiratory motoneurons as well as …