Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection

GC Ulett, M Totsika, K Schaale, AJ Carey… - Current opinion in …, 2013 - Elsevier
Urinary tract infections (UTI) are among the most common infectious diseases of humans
and are the most common nosocomial infections in the developed world. It is estimated that …

Invasion of host cells and tissues by uropathogenic bacteria

AJ Lewis, AC Richards… - Urinary Tract Infections …, 2017 - Wiley Online Library
The ability of bacterial pathogens to invade host cells can have profound effects on the
establishment, persistence, and propagation of infections. By entering host cells and …

Epidemiology and Virulence of Klebsiella pneumoniae

S Clegg, CN Murphy - Urinary Tract Infections: Molecular …, 2017 - Wiley Online Library
Awareness of the role of Klebsiella pneumoniae as an important opportunistic pathogen of
the urinary tract in compromised individuals and hospitalized patients has increased over …

Specificity in S-nitrosylation: a short-range mechanism for NO signaling?

A Martinez-Ruiz, IM Araújo… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Nitric oxide (NO) classical and less classical signaling mechanisms (through
interaction with soluble guanylate cyclase and cytochrome c oxidase, respectively) operate …

Strengths and limitations of model systems for the study of urinary tract infections and related pathologies

AE Barber, JP Norton, TJ Wiles… - … and Molecular Biology …, 2016 - Am Soc Microbiol
Urinary tract infections (UTIs) are some of the most common bacterial infections worldwide
and are a source of substantial morbidity among otherwise healthy women. UTIs can be …

[HTML][HTML] From infection to immunotherapy: host immune responses to bacteria at the bladder mucosa

MA Ingersoll, ML Albert - Mucosal immunology, 2013 - Elsevier
The pathogenesis of urinary tract infection and mechanisms of the protective effect of
Bacillus Calmette–Guerin (BCG) therapy for bladder cancer highlight the importance of …

[HTML][HTML] Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection

AE Lin, FC Beasley, J Olson, N Keller… - PLoS …, 2015 - journals.plos.org
Uropathogenic E. coli (UPEC) is the primary cause of urinary tract infections (UTI) affecting
approximately 150 million people worldwide. Here, we revealed the importance of …

[HTML][HTML] The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection

M Shepherd, MES Achard, A Idris, M Totsika… - Scientific reports, 2016 - nature.com
Nitric oxide (NO) is a toxic free radical produced by neutrophils and macrophages in
response to infection. Uropathogenic Escherichia coli (UPEC) induces a variety of defence …

[HTML][HTML] Production of the Escherichia coli Common Pilus by Uropathogenic E. coli Is Associated with Adherence to HeLa and HTB-4 Cells and Invasion of Mouse …

Z Saldaña, MA De la Cruz, EM Carrillo-Casas… - PLoS …, 2014 - journals.plos.org
Uropathogenic Escherichia coli (UPEC) strains cause urinary tract infections and employ
type 1 and P pili in colonization of the bladder and kidney, respectively. Most intestinal and …

[HTML][HTML] Uropathogenic Escherichia coli invades bladder epithelial cells by activating kinase networks in host cells

WJ Kim, AE Shea, JH Kim, Y Daaka - Journal of Biological Chemistry, 2018 - ASBMB
Uropathogenic Escherichia coli (UPEC) is the causative bacterium in most urinary tract
infections (UTIs). UPEC cells adhere to and invade bladder epithelial cells (BECs) and …