Natural killer cells in antitumour adoptive cell immunotherapy
TJ Laskowski, A Biederstädt, K Rezvani - Nature Reviews Cancer, 2022 - nature.com
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …
Natural killer cells in cancer biology and therapy
SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
[HTML][HTML] TIGIT in cancer immunotherapy
JM Chauvin, HM Zarour - Journal for immunotherapy of cancer, 2020 - ncbi.nlm.nih.gov
Tumors evade immune-mediated recognition through multiple mechanisms of immune
escape. On chronic tumor antigen exposure, T cells become dysfunctional/exhausted and …
escape. On chronic tumor antigen exposure, T cells become dysfunctional/exhausted and …
Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders
NA Maskalenko, D Zhigarev… - Nature reviews Drug …, 2022 - nature.com
Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …
TIGIT, the next step towards successful combination immune checkpoint therapy in cancer
Z Ge, MP Peppelenbosch, D Sprengers… - Frontiers in …, 2021 - frontiersin.org
T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory receptor expressed
on several types of lymphocytes. Efficacy of antibody blockade of TIGIT in cancer …
on several types of lymphocytes. Efficacy of antibody blockade of TIGIT in cancer …
Exploiting innate immunity for cancer immunotherapy
M Yi, T Li, M Niu, Q Mei, B Zhao, Q Chu, Z Dai, K Wu - Molecular cancer, 2023 - Springer
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …
However, most of these immunomodulatory strategies focus on harnessing adaptive …
[HTML][HTML] TIGIT-CD226-PVR axis: advancing immune checkpoint blockade for cancer immunotherapy
Recent advances in understanding the roles of immune checkpoints in allowing tumors to
circumvent the immune system have led to successful therapeutic strategies that have …
circumvent the immune system have led to successful therapeutic strategies that have …
[HTML][HTML] Emerging concepts in PD-1 checkpoint biology
KE Pauken, JA Torchia, A Chaudhri, AH Sharpe… - Seminars in …, 2021 - Elsevier
The PD-1 pathway is a cornerstone in immune regulation. While the PD-1 pathway has
received considerable attention for its role in contributing to the maintenance of T cell …
received considerable attention for its role in contributing to the maintenance of T cell …
Innovative breakthroughs facilitated by single-cell multi-omics: manipulating natural killer cell functionality correlates with a novel subcategory of melanoma cells
Z Zhao, Y Ding, LJ Tran, G Chai, L Lin - Frontiers in immunology, 2023 - frontiersin.org
Background Melanoma is typically regarded as the most dangerous form of skin cancer.
Although surgical removal of in situ lesions can be used to effectively treat metastatic …
Although surgical removal of in situ lesions can be used to effectively treat metastatic …
Novel strategies for cancer immunotherapy: counter-immunoediting therapy
S Liu, Q Sun, X Ren - Journal of Hematology & Oncology, 2023 - Springer
The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …
especially the application of immune checkpoint inhibitors in clinical practice. Although …