Novel drug delivery systems and disease models for pulmonary fibrosis

R Li, Y Jia, X Kong, Y Nie, Y Deng, Y Liu - Journal of Controlled Release, 2022 - Elsevier
Pulmonary fibrosis (PF) is a serious and progressive lung disease which is possibly life-
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …

3D bioprinting strategies, challenges, and opportunities to model the lung tissue microenvironment and its function

M Barreiro Carpio, M Dabaghi, J Ungureanu… - … in Bioengineering and …, 2021 - frontiersin.org
Human lungs are organs with an intricate hierarchical structure and complex composition;
lungs also present heterogeneous mechanical properties that impose dynamic stress on …

Harnessing organs-on-a-chip to model tissue regeneration

DN Tavakol, S Fleischer, G Vunjak-Novakovic - Cell Stem Cell, 2021 - cell.com
Tissue engineering has markedly matured since its early beginnings in the 1980s. In
addition to the original goal to regenerate damaged organs, the field has started to explore …

Lung organoids—the ultimate tool to dissect pulmonary diseases?

V Bosáková, M De Zuani, L Sládková… - Frontiers in Cell and …, 2022 - frontiersin.org
Organoids are complex multicellular three-dimensional (3D) in vitro models that are
designed to allow accurate studies of the molecular processes and pathologies of human …

Morphogenesis beyond in vivo

Y Liu, X Xue, S Sun, N Kobayashi, YS Kim… - Nature Reviews …, 2024 - nature.com
Morphogenetic events during development shape the body plan and establish structural
foundations for tissue forms and functions. Acquiring spatiotemporal information of …

Human Lung Organoids—A Novel Experimental and Precision Medicine Approach

L Kühl, P Graichen, N von Daacke, A Mende… - Cells, 2023 - mdpi.com
The global burden of respiratory diseases is very high and still on the rise, prompting the
need for accurate models for basic and translational research. Several model systems are …

Advanced in vitro lung models for drug and toxicity screening: the promising role of induced pluripotent stem cells

A Moreira, M Müller, PF Costa, Y Kohl - Advanced Biology, 2022 - Wiley Online Library
The substantial socioeconomic burden of lung diseases, recently highlighted by the
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …

Organoid: a powerful tool to study lung regeneration and disease

T Lu, Y Cao, P Zhao, S Shen, Y Xi - Cell Regeneration, 2021 - Springer
Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells
or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue …

Lung organoids in smoking research: current advances and future promises

H Agraval, HW Chu - Biomolecules, 2022 - mdpi.com
Tobacco smoking has been established to contribute to the pathogenesis of various
respiratory diseases including chronic obstructive pulmonary disease (COPD), lung cancer …

Lung organoids as model to study SARS-CoV-2 infection

L Peng, L Gao, X Wu, Y Fan, M Liu, J Chen, J Song… - Cells, 2022 - mdpi.com
Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a global pandemic and has severely affected …