Novel drug delivery systems and disease models for pulmonary fibrosis
R Li, Y Jia, X Kong, Y Nie, Y Deng, Y Liu - Journal of Controlled Release, 2022 - Elsevier
Pulmonary fibrosis (PF) is a serious and progressive lung disease which is possibly life-
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …
3D bioprinting strategies, challenges, and opportunities to model the lung tissue microenvironment and its function
M Barreiro Carpio, M Dabaghi, J Ungureanu… - … in Bioengineering and …, 2021 - frontiersin.org
Human lungs are organs with an intricate hierarchical structure and complex composition;
lungs also present heterogeneous mechanical properties that impose dynamic stress on …
lungs also present heterogeneous mechanical properties that impose dynamic stress on …
Harnessing organs-on-a-chip to model tissue regeneration
Tissue engineering has markedly matured since its early beginnings in the 1980s. In
addition to the original goal to regenerate damaged organs, the field has started to explore …
addition to the original goal to regenerate damaged organs, the field has started to explore …
Lung organoids—the ultimate tool to dissect pulmonary diseases?
V Bosáková, M De Zuani, L Sládková… - Frontiers in Cell and …, 2022 - frontiersin.org
Organoids are complex multicellular three-dimensional (3D) in vitro models that are
designed to allow accurate studies of the molecular processes and pathologies of human …
designed to allow accurate studies of the molecular processes and pathologies of human …
Morphogenesis beyond in vivo
Morphogenetic events during development shape the body plan and establish structural
foundations for tissue forms and functions. Acquiring spatiotemporal information of …
foundations for tissue forms and functions. Acquiring spatiotemporal information of …
Human Lung Organoids—A Novel Experimental and Precision Medicine Approach
L Kühl, P Graichen, N von Daacke, A Mende… - Cells, 2023 - mdpi.com
The global burden of respiratory diseases is very high and still on the rise, prompting the
need for accurate models for basic and translational research. Several model systems are …
need for accurate models for basic and translational research. Several model systems are …
Advanced in vitro lung models for drug and toxicity screening: the promising role of induced pluripotent stem cells
The substantial socioeconomic burden of lung diseases, recently highlighted by the
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
Organoid: a powerful tool to study lung regeneration and disease
T Lu, Y Cao, P Zhao, S Shen, Y Xi - Cell Regeneration, 2021 - Springer
Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells
or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue …
or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue …
Lung organoids in smoking research: current advances and future promises
H Agraval, HW Chu - Biomolecules, 2022 - mdpi.com
Tobacco smoking has been established to contribute to the pathogenesis of various
respiratory diseases including chronic obstructive pulmonary disease (COPD), lung cancer …
respiratory diseases including chronic obstructive pulmonary disease (COPD), lung cancer …
Lung organoids as model to study SARS-CoV-2 infection
L Peng, L Gao, X Wu, Y Fan, M Liu, J Chen, J Song… - Cells, 2022 - mdpi.com
Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a global pandemic and has severely affected …
coronavirus 2 (SARS-CoV-2), has become a global pandemic and has severely affected …