Regulation of immune responses by the airway epithelial cell landscape

RJ Hewitt, CM Lloyd - Nature Reviews Immunology, 2021 - nature.com
The community of cells lining our airways plays a collaborative role in the preservation of
immune homeostasis in the lung and provides protection from the pathogens and pollutants …

Internal senses of the vagus nerve

SL Prescott, SD Liberles - Neuron, 2022 - cell.com
The vagus nerve is an indispensable body-brain connection that controls vital aspects of
autonomic physiology like breathing, heart rate, blood pressure, and gut motility, reflexes …

Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit

MS Nadjsombati, JW McGinty, MR Lyons-Cohen… - Immunity, 2018 - cell.com
In the small intestine, type 2 responses are regulated by a signaling circuit that involves tuft
cells and group 2 innate lymphoid cells (ILC2s). Here, we identified the microbial metabolite …

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

J Von Moltke, M Ji, HE Liang, RM Locksley - Nature, 2016 - nature.com
Parasitic helminths and allergens induce a type 2 immune response leading to profound
changes in tissue physiology, including hyperplasia of mucus-secreting goblet cells and …

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

CN Miller, I Proekt, J von Moltke, KL Wells… - Nature, 2018 - nature.com
The thymus is responsible for generating a diverse yet self-tolerant pool of T cells. Although
the thymic medulla consists mostly of developing and mature AIRE+ epithelial cells, recent …

Regulation of immune responses by tuft cells

C Schneider, CE O'Leary, RM Locksley - Nature Reviews Immunology, 2019 - nature.com
Tuft cells are rare, secretory epithelial cells that generated scant immunological interest until
contemporaneous reports in 2016 linked tuft cells with type 2 immunity in the small intestine …

Therapeutic potential of ectopic olfactory and taste receptors

SJ Lee, I Depoortere, H Hatt - Nature Reviews Drug Discovery, 2019 - nature.com
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and
gustatory taste bud cells, where they transmit real-time sensory signals to the brain …

[图书][B] Principles and practice of phytotherapy: modern herbal medicine

K Bone, S Mills - 2012 - books.google.com
The authoritative and comprehensive modern textbook on western herbal medicine-now in
its second edition This long-awaited second edition of Principles and Practice of …

An update on extra-oral bitter taste receptors

K Tuzim, A Korolczuk - Journal of translational medicine, 2021 - Springer
Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family
A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of …

A succinate/SUCNR1-brush cell defense program in the tracheal epithelium

A Perniss, B Boonen, S Tonack, M Thiel, K Poharkar… - Science …, 2023 - science.org
Host-derived succinate accumulates in the airways during bacterial infection. Here, we show
that luminal succinate activates murine tracheal brush (tuft) cells through a signaling …