The activation of Rho GTPases is mediated by guanine-nucleotide exchange factors (GEFs),
which catalyze the exchange of GDP for GTP. Rho-GEFs are a very diverse family, with> 70 …

Rho guanosine triphosphatases (GTPases) are key regulators in a number of cellular
functions, including actin cytoskeleton remodeling and vesicle traffic. Traditionally, Rho …

The vasculature tailors to the needs of different tissues and organs. Molecular, structural,
and functional specializations are observed in different vascular beds, but few genetic …

α and βPIX belong to the group of guanine nucleotide exchange factors (GEFs) that mediate
activation of members of the Rho GTPase family, in particular Rac1 and Cdc42, by …

Synaptic connections between neurons are essential for every facet of human cognition and
are thus regulated with extreme precision. Rho-family GTPases, molecular switches that …

Collective epithelial migration is important throughout embryonic development. The
underlying mechanisms are poorly understood but likely involve spatially localized …

The characteristic six layers of the mammalian neocortex develop sequentially as neurons
are generated by neural progenitors and subsequently migrate past older neurons to their …

Microtubules are a major cytoskeletal component of neurites, and the regulation of
microtubule stability is essential for neurite morphogenesis. βPix (ARHGEF7) is a guanine …

PIX (PAK1-interacting exchange factor beta, encoded by ARHGEF7) and PAK1 (p21
activated kinase) are interacting proteins that form a signaling module that mediates a …

Axon regeneration is essential for successful recovery after peripheral nerve injury. Although
growth cone reformation and axonal extension are crucial steps in axonal regeneration, the …