Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Gastrointestinal biofilms in health and disease

JP Motta, JL Wallace, AG Buret, C Deraison… - Nature Reviews …, 2021 - nature.com
Microorganisms colonize various ecological niches in the human habitat, as they do in
nature. Predominant forms of multicellular communities called biofilms colonize human …

Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice

JL Drewes, J Chen, NO Markham, RJ Knippel… - Cancer discovery, 2022 - AACR
Defining the complex role of the microbiome in colorectal cancer and the discovery of novel,
protumorigenic microbes are areas of active investigation. In the present study, culturing and …

Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 …

C Kong, X Yan, Y Zhu, H Zhu, Y Luo, P Liu… - Cancer Research, 2021 - AACR
Emerging research has revealed regulation of colorectal cancer metabolism by bacteria.
Fusobacterium nucleatum (Fn) plays a crucial role in the development of colorectal cancer …

[HTML][HTML] Host/microbiota interactions in health and diseases—Time for mucosal microbiology!

N Daniel, E Lécuyer, B Chassaing - Mucosal Immunology, 2021 - Elsevier
During the last 20 years, a new field of research delineating the importance of the microbiota
in health and diseases has emerged. Inappropriate host-microbiota interactions have been …

TP53 Gain-of-Function and Non–Gain-of-Function Mutations Are Differentially Associated With Sidedness-Dependent Prognosis in Metastatic Colorectal Cancer

M Pan, C Jiang, P Tse, N Achacoso… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE To examine the association of gain-of-function (GOF) and non–gain-of-function
(non-GOF) TP53 mutations with prognosis of metastatic right-sided (RCC) versus left-sided …

MicroRNA and gut microbiota: Tiny but mighty—Novel insights into their cross-talk in inflammatory bowel disease pathogenesis and therapeutics

M Casado-Bedmar, E Viennois - Journal of Crohn's and Colitis, 2022 - academic.oup.com
Abstract MicroRNAs [miRNAs], small non-coding RNAs, have recently been described as
crucial contributors to intestinal homeostasis. They can interact with the gut microbiota in a …

Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities

B Jandl, S Dighe, C Gasche… - Clinical microbiology …, 2024 - journals.asm.org
The human intestinal tract harbors a profound variety of microorganisms that live in
symbiosis with the host and each other. It is a complex and highly dynamic environment …

MicroRNAs regulate intestinal immunity and gut microbiota for gastrointestinal health: A comprehensive review

K Bi, X Zhang, W Chen, H Diao - Genes, 2020 - mdpi.com
MicroRNAs are small non-coding RNAs regulating gene expression at the post-
transcriptional level. The regulation of microRNA expression in the gut intestine is gradually …

Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation

M Casado-Bedmar, M Roy, L Berthet, JP Hugot… - Gut …, 2024 - Taylor & Francis
Inflammatory bowel diseases (IBD) etiology is multifactorial. Luminal microRNAs (miRNAs)
have been suspected to play a role in the promotion of chronic inflammation, but the extent …