Cellular reprogramming and epigenetic rejuvenation
Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the
generation of induced pluripotent stem cells, have delivered preliminary evidence that …
generation of induced pluripotent stem cells, have delivered preliminary evidence that …
The hallmarks of fibroblast ageing
J Tigges, J Krutmann, E Fritsche, J Haendeler… - Mechanisms of ageing …, 2014 - Elsevier
Ageing is influenced by the intrinsic disposition delineating what is maximally possible and
extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic …
extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic …
A practical guide to linking brain-wide gene expression and neuroimaging data
The recent availability of comprehensive, brain-wide gene expression atlases such as the
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …
[HTML][HTML] The transcriptional landscape of age in human peripheral blood
MJ Peters, R Joehanes, LC Pilling… - Nature …, 2015 - nature.com
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …
to increased disease susceptibility remain inadequately understood. Here we perform a …
[HTML][HTML] DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing
The ability to estimate the age of the donor from recovered biological material at a crime
scene can be of substantial value in forensic investigations. Aging can be complex and is …
scene can be of substantial value in forensic investigations. Aging can be complex and is …
Predicting age from the transcriptome of human dermal fibroblasts
JG Fleischer, R Schulte, HH Tsai, S Tyagi, A Ibarra… - Genome biology, 2018 - Springer
Biomarkers of aging can be used to assess the health of individuals and to study aging and
age-related diseases. We generate a large dataset of genome-wide RNA-seq profiles of …
age-related diseases. We generate a large dataset of genome-wide RNA-seq profiles of …
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Transcriptomic imputation approaches combine eQTL reference panels with large-scale
genotype data in order to test associations between disease and gene expression. These …
genotype data in order to test associations between disease and gene expression. These …
Synaptic and transcriptionally downregulated genes are associated with cortical thickness differences in autism
Differences in cortical morphology—in particular, cortical volume, thickness and surface
area—have been reported in individuals with autism. However, it is unclear what aspects of …
area—have been reported in individuals with autism. However, it is unclear what aspects of …
Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts
Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The
ability to recapitulate age-related characteristics of human neurons in culture will offer …
ability to recapitulate age-related characteristics of human neurons in culture will offer …
A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
S Sood, IJ Gallagher, K Lunnon, E Rullman… - Genome biology, 2015 - Springer
Background Diagnostics of the human ageing process may help predict future healthcare
needs or guide preventative measures for tackling diseases of older age. We take a …
needs or guide preventative measures for tackling diseases of older age. We take a …