Aging is an inevitable process characterized by progressive loss of physiological integrity
and increased susceptibility to cancer, diabetes, cardiovascular, and neurodegenerative …

Organisms from all kingdoms of life synthesize L‐serine (L‐Ser) from 3‐phosphoglycerate
through the phosphorylated pathway, a three‐step diversion of glycolysis. Phosphoserine …

Oxidation–reduction post-translational modifications (redox-PTMs) are chemical alterations
to amino acids of proteins. Redox-PTMs participate in the regulation of protein conformation …

S-Nitrosylation of cysteine residues is an important molecular mechanism for dynamic, post-
translational regulation of several proteins, providing a ubiquitous redox regulation. Cys …

Heme proteins are a diverse group that includes several unrelated families. Their biological
function is mainly associated with the reactivity of the heme group, which—among several …

The intricate signaling network within the central nervous system (CNS) involving N-methyl-
d-aspartate receptors (NMDARs) has been recognized as a key player in severe …

Phosphoserine phosphatase (PSP) catalyzes the final step of de novo L-serine biosynthesis—
the hydrolysis of phosphoserine to serine and inorganic phosphate—in humans, bacteria …

Human serine racemase (hSR) catalyses racemisation of L-serine to D-serine, the latter of
which is a co-agonist of the NMDA subtype of glutamate receptors that are important in …

Human serine racemase (hSR) is a pyridoxal-5′-phosphate (PLP)-dependent dimer that
catalyzes the formation of D-serine from L-serine, as well as the dehydration of both L-and D …

In the central nervous system, the flavoprotein D-amino acid oxidase is responsible for
catabolizing D-serine, the main endogenous coagonist of N-methyl-D-aspartate receptor …