In this review, subtypes of functional α1-adrenoceptor are discussed. These are cell
membrane receptors, belonging to the seven-transmembrane-spanning G-protein-linked …

α1‐Adrenoceptors are seven transmembrane domain GPCRs involved in numerous
physiological functions controlled by the endogenous catecholamines, noradrenaline and …

Evidence from cell, animal, and human studies demonstrates that α1-adrenergic receptors
mediate adaptive and protective effects in the heart. These effects may be particularly …

This review examines the functions of α 1-adrenoceptor subtypes, particularly in terms of
contraction of smooth muscle. There are 3 subtypes of α 1-adrenoceptor, α 1A-α 1B-and α …

This review is based on the JR V ane M edal L ecture presented at the BPS W inter M eeting
in D ecember 2011 by JC M c G rath. A recording of the lecture is included as supporting …

Background and purpose: α1‐Adrenoceptor agonists induce Ca2+‐transients in endothelial
cells (ECs) of arterioles. However, the presence of α1‐adrenoceptors on arteriolar ECs has …

There is considerable evidence that many disease are associated with endothelial
dysfunction and reduced nitric oxide production such as hypertension, obesity …

The retina is a part of the central nervous system, a thin multilayer with neuronal lamination,
responsible for detecting, preprocessing, and sending visual information to the brain. Many …

Abstract Alpha-1-adrenergic receptors (α1-ARs) regulate coronary arterial blood flow by
binding catecholamines, norepinephrine (NE), and epinephrine (EPI), causing …

Maternal cardiovascular diseases, including hypertension and cardiac conditions, are
associated with poor fetal outcomes. A range of adrenergic antihypertensive and …