Significance of long chain polyunsaturated fatty acids in human health

R Zárate, N el Jaber-Vazdekis, N Tejera… - Clinical and translational …, 2017 - Springer
In the last decades, the development of new technologies applied to lipidomics has
revitalized the analysis of lipid profile alterations and the understanding of the underlying …

Tracing the peopling of the world through genomics

R Nielsen, JM Akey, M Jakobsson, JK Pritchard… - Nature, 2017 - nature.com
Advances in the sequencing and the analysis of the genomes of both modern and ancient
peoples have facilitated a number of breakthroughs in our understanding of human …

Genomic analyses from non-invasive prenatal testing reveal genetic associations, patterns of viral infections, and Chinese population history

S Liu, S Huang, F Chen, L Zhao, Y Yuan, SS Francis… - Cell, 2018 - cell.com
We analyze whole-genome sequencing data from 141,431 Chinese women generated for
non-invasive prenatal testing (NIPT). We use these data to characterize the population …

Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases

WH Schunck, A Konkel, R Fischer… - Pharmacology & …, 2018 - Elsevier
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

The role of the microbiota in human genetic adaptation

TA Suzuki, RE Ley - Science, 2020 - science.org
BACKGROUND When human populations expanded across the globe, they adapted
genetically to local environments in response to novel selection pressures. Drivers of …

[HTML][HTML] Best practices for the design, laboratory analysis, and reporting of trials involving fatty acids

JT Brenna, M Plourde, KD Stark, PJ Jones… - The American journal of …, 2018 - Elsevier
Fatty acids are among the most studied nutrients in human metabolism and health.
Endogenous fatty acid status influences health and disease via multiple mechanisms at all …

The sources, synthesis and biological actions of omega-3 and omega-6 fatty acids in red meat: An overview

EN Ponnampalam, AJ Sinclair, BWB Holman - Foods, 2021 - mdpi.com
The maximisation of available resources for animal production, food security and
maintenance of human–animal wellbeing is important for an economically viable, resilient …

FADS1 and the Timing of Human Adaptation to Agriculture

S Mathieson, I Mathieson - Molecular biology and evolution, 2018 - academic.oup.com
Variation at the FADS1/FADS2 gene cluster is functionally associated with differences in
lipid metabolism and is often hypothesized to reflect adaptation to an agricultural diet. Here …

Precision nutrition and omega-3 polyunsaturated fatty acids: A case for personalized supplementation approaches for the prevention and management of human …

FH Chilton, R Dutta, LM Reynolds, S Sergeant… - Nutrients, 2017 - mdpi.com
Background: Dietary essential omega-6 (n-6) and omega-3 (n-3) 18 carbon (18C-)
polyunsaturated fatty acids (PUFA), linoleic acid (LA) and α-linolenic acid (ALA), can be …

Selection in Europeans on fatty acid desaturases associated with dietary changes

MT Buckley, F Racimo, ME Allentoft… - Molecular biology …, 2017 - academic.oup.com
FADS genes encode fatty acid desaturases that are important for the conversion of short
chain polyunsaturated fatty acids (PUFAs) to long chain fatty acids. Prior studies indicate that …