Risks of Infectious Disease in Xenotransplantation | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …

Genetically modified xenografts are one of the most promising solutions to the discrepancy
between the numbers of available human organs for transplantation and potential recipients …

Background A genetically engineered pig cardiac xenotransplantation was done on Jan 7,
2022, in a non-ambulatory male patient, aged 57 years, with end-stage heart failure, and on …

The clinical applicability of porcine xenotransplantation—a long-investigated alternative to
the scarce availability of human organs for patients with organ failure—is limited by …

Background Cross-species immunological incompatibilities have hampered pig-to-human
xenotransplantation, but porcine genome engineering recently enabled the first successful …

The pig is an omnivorous, monogastric species with many advantages to serve as an animal
model for human diseases. There are very high similarities to humans in anatomy and …

In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI)
and AKI to chronic kidney disease (CKD) progression has been revisited as our …

Although major advances in genomics have initiated an exciting new era of research, a lack
of information regarding cis-regulatory elements has limited the genetic improvement or …

The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …