Exercise has long been known for its active role in improving physical fitness and sustaining
health. Regular moderate-intensity exercise improves all aspects of human health and is …

Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

A sedentary lifestyle, chronic inflammation and leukocytosis increase atherosclerosis;
however, it remains unclear whether regular physical activity influences leukocyte …

The integrity and composition of the tumour microenvironment (TME) is highly plastic,
undergoing constant remodelling in response to instructive signals derived from alterations …

Somatic stem cell (SSC) dysfunction is typical for different progeroid phenotypes in mice with
genomic DNA repair defects. MtDNA mutagenesis in mice with defective Polg exonuclease …

Exercise, stress, sleep and diet are four distinct but intertwined lifestyle factors that influence
the cardiovascular system. Abundant epidemiological, clinical and preclinical studies have …

Aging promotes accumulation of reactive oxygen/nitrogen species (ROS/RNS) in
cardiomyocytes, which leads to contractile dysfunction and cardiac abnormalities. These …

Obesity is characterized by low-grade inflammation, which is accompanied by increased
accumulation of immune cells in peripheral tissues including adipose tissue (AT), skeletal …

Physical inactivity is one of the leading contributors to worldwide morbidity and mortality.
The elderly are particularly susceptible since the features of physical inactivity overlap with …

Observational studies have suggested that physical activity may be associated with
improved survival after cancer treatment. However, data from controlled clinical trials are …