Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …

Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the
leading cause of death worldwide. It is well established that cholesterol ester-enriched foam …

Background: Cardiovascular risk in diabetes remains elevated despite glucose-lowering
therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages …

Despite the decades-old knowledge that diabetes mellitus is a major risk factor for
cardiovascular disease, the reasons for this association are only partially understood. While …

Atherosclerotic Plaque Healing Atherosclerotic plaque rupture and erosion result in acute
coronary syndromes. Plaque healing after initial disruption has been less extensively …

Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

Inflammation originating from the adipose tissue is considered to be one of the main driving
forces for the development of insulin resistance and type 2 diabetes in obese individuals …

Atherosclerosis is a chronic inflammatory disease, and developing therapies to promote its
regression is an important clinical goal. We previously established that atherosclerosis …

The prevalence of diabetes mellitus will likely increase globally from 371 million individuals
in 2013 to 552 million individuals in 2030. This epidemic is mainly attributable to type 2 …