Emerging role of RNA acetylation modification ac4C in diseases: current advances and future challenges
J Luo, J Cao, C Chen, H Xie - Biochemical Pharmacology, 2023 - Elsevier
The oldest known highly conserved modification of RNA, N4-acetylcytidine, is widely
distributed from archaea to eukaryotes and acts as a posttranscriptional chemical …
distributed from archaea to eukaryotes and acts as a posttranscriptional chemical …
The potential role of m6A reader YTHDF1 as diagnostic biomarker and the signaling pathways in tumorigenesis and metastasis in pan-cancer
Y Zhu, J Li, H Yang, X Yang, Y Zhang, X Yu, Y Li… - Cell Death …, 2023 - nature.com
Abstract m6A is an important RNA methylation in progression of various human cancers. As
the m6A reader protein, YTHDF1 is reported to accelerate m6A-modified mRNAs translation …
the m6A reader protein, YTHDF1 is reported to accelerate m6A-modified mRNAs translation …
NAT10-mediated N4-acetylcytidine modification is required for meiosis entry and progression in male germ cells
Post-transcriptional RNA modifications critically regulate various biological processes. N 4-
acetylcytidine (ac4C) is an epi-transcriptome, which is highly conserved in all species …
acetylcytidine (ac4C) is an epi-transcriptome, which is highly conserved in all species …
ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N 6-methyladenosine methylation
L Bai, Y Xiang, M Tang, S Liu, Q Chen, Q Chen… - Nature …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) maintains maternal RNA stability in oocytes. One
regulator of m6A, ALKBH5, reverses m6A deposition and is essential in RNA metabolism …
regulator of m6A, ALKBH5, reverses m6A deposition and is essential in RNA metabolism …
Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Shaziling Pig Testicular Development
C Chen, X Tang, S Yan, A Yang, J Xiang… - International Journal of …, 2023 - mdpi.com
RNA N 6-methyladenosine (m6A) modification is one of the principal post-transcriptional
modifications and plays a dynamic role in testicular development and spermatogenesis …
modifications and plays a dynamic role in testicular development and spermatogenesis …
Effect of paternal diet on spermatogenesis and offspring health: Focus on epigenetics and interventions with food bioactive compounds
Infertility is a growing public health problem. Consumption of antioxidant bioactive food
compounds (BFCs) that include micronutrients and non-nutrients has been highlighted as a …
compounds (BFCs) that include micronutrients and non-nutrients has been highlighted as a …
The role of N6-methyladenosine modification in benzene-induced testicular damage and the protective effect of melatonin
L Han, J Wang, L Zhang, J Jing, W Zhang, Z Liu, A Gao - Chemosphere, 2023 - Elsevier
Benzene is a universal ambient pollutant. Population-based studies have shown that
benzene exposure affects male fertility. However, the mechanism of benzene-induced …
benzene exposure affects male fertility. However, the mechanism of benzene-induced …
LncRNA CASC11 Promotes Hepatocellular Carcinoma Progression via Upregulation of UBE2T in am6A-Dependent Manner
F Chen, M Li, L Wang - Frontiers in Oncology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most frequent malignancies and the third
leading cause of cancer-related deaths worldwide. Besides, it has been revealed that long …
leading cause of cancer-related deaths worldwide. Besides, it has been revealed that long …
Reading the m6A-encoded epitranscriptomic information in development and diseases
Y Chen, Z Zhou, Y Chen, D Chen - Cell & Bioscience, 2024 - Springer
Abstract N 6-methyladenosine (m6A) represents the most prevalent internal and reversible
modification on RNAs. Different cell types display their unique m6A profiles, which are …
modification on RNAs. Different cell types display their unique m6A profiles, which are …
Alteration of RNA modification signature in human sperm correlates with sperm motility
H Guo, X Shen, H Hu, P Zhou, T He… - Molecular Human …, 2022 - academic.oup.com
RNA modifications, which are introduced post-transcriptionally, have recently been assigned
pivotal roles in the regulation of spermatogenesis and embryonic development. However …
pivotal roles in the regulation of spermatogenesis and embryonic development. However …