Adverse cardiovascular effects and potential molecular mechanisms of DEHP and its metabolites—a review

ZJ Wen, ZY Wang, YF Zhang - Science of The Total Environment, 2022 - Elsevier
Currently, cardiovascular disease (CVD) is a health hazard that is associated with
progressive deterioration upon exposure to environmental pollutants. Di (2-ethylhexyl) …

Deconvoluting the complexity of reactive oxygen species (ROS) in neurodegenerative diseases

Y Zhou, Y Zhen, G Wang, B Liu - Frontiers in Neuroanatomy, 2022 - frontiersin.org
Neurodegenerative diseases (NDs) have been becoming a serious public health concern as
the world's population continues to ageing, demanding for the discovery of more effective …

Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1α/HO-1 signaling pathway in mouse testes

Y Wu, J Wang, T Zhao, J Chen, L Kang, Y Wei… - Journal of hazardous …, 2022 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) is an extensively used plasticizer and has been
shown to cause reproductive dysfunction in humans and model animals. However, the exact …

DEHP-induced mitophagy and mitochondrial damage in the heart are associated with dysregulated mitochondrial biogenesis

H Zhang, Y Zhao, JG Cui, XN Li, JL Li - Food and Chemical Toxicology, 2022 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer widely used in agricultural and
industrial plastic products. Many researchers have demonstrated that DEHP can cause …

DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity

L Yang, L Jiang, X Sun, J Li, N Wang, X Liu… - Food and Chemical …, 2022 - Elsevier
Abstract Exposure to Di (2-ethylhexyl) phthalate (DEHP) has been associated with toxic
effects of the reproductive system. However, the exact mechanism remains to be elucidated …

ROS-activatable biomimetic interface mediates in-situ bioenergetic remodeling of osteogenic cells for osteoporotic bone repair

M Chen, M Li, Y Wei, C Xue, M Chen, Y Fei, L Tan… - Biomaterials, 2022 - Elsevier
Bioenergy (ATP) is essentially required for supporting the osteogenic differentiation of bone
marrow mesenchymal stem cells (MSCs). However, factors such as high ROS levels and …

[HTML][HTML] PM2. 5 increases susceptibility to acute exacerbation of COPD via NOX4/Nrf2 redox imbalance-mediated mitophagy

X Fan, T Dong, K Yan, X Ci, L Peng - Redox Biology, 2023 - Elsevier
The increasing abundance of fine particulate matter (PM2. 5) in the environment has
increased susceptibility to acute exacerbation of COPD (AECOPD). During PM2. 5 …

Highly sensitive and selective photoelectrochemical aptasensing of di-2-ethylhexyl phthalate based on graphene quantum dots decorated TiO2 nanotube arrays

Y Deng, W Yan, Y Guo, Q Wang, Y Bi, C Dong… - Journal of Hazardous …, 2022 - Elsevier
A photoelectrochemical (PEC) sensing platform for di-2-ethylhexyl phthalate (DEHP) was
constructed using graphene quantum dots decorated TiO 2 nanotube arrays (GQDs …

[HTML][HTML] Neurotoxicity and the potential molecular mechanisms of mono-2-ethylhexyl phthalic acid (MEHP) in zebrafish

Y Liu, WB Huo, JY Deng, QP Tang, JX Wang… - Ecotoxicology and …, 2023 - Elsevier
Abstract Mono-2-ethylhexyl phthalic acid (MEHP) is the most toxic metabolite of plasticizer di-
2-ethylhexyl phthalic acid (DEHP), and there is limited information available on the effects of …

Mitocytosis Is Critical for Phthalate-Induced Injury to the Ovarian Granulosa Cell Layer in Quail (Coturnix japonica)

XY Ma, Y Zhu, YR Xu, MAU Saleem… - Journal of Agricultural …, 2023 - ACS Publications
Phthalates are widely used synthetic chemicals that determine endocrine disruption effects
on female reproductivity and oviposition. Our study demonstrated that the mitochondrial …