Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …

Apical extracellular matrices (aECMs) coat the exposed surfaces of animal bodies to shape
tissues, influence social interactions, and protect against pathogens and other …

Lysosomes play important roles in cellular degradation to maintain cell homeostasis. In
order to understand whether and how lysosomes alter with age and contribute to lifespan …

Apical extracellular matrices (aECMs) are complex extracellular compartments that form
important interfaces between animals and their environment. In the adult C. elegans cuticle …

Lysosomes are degradation and signalling centres crucial for homeostasis, development
and ageing. To meet diverse cellular demands, lysosomes remodel their morphology and …

Apical extracellular matrices (aECMs) coat exposed surfaces of epithelia to shape
developing tissues and protect them from environmental insults. Despite their widespread …

Wounding and infection trigger a protective innate immune response that includes the
production of antimicrobial peptides in the affected tissue as well as increased sleep. Little is …

Apical extracellular matrices (aECMs) form a physical barrier to the environment. In
Caenorhabditis elegans, the epidermal aECM, the cuticle, is composed mainly of different …

Lysosomal integrity is vital for cell homeostasis, but the underlying mechanisms are poorly
understood. Here, we identify CLH-6, the C. elegans ortholog of the lysosomal Cl−/H+ …

Hemidesmosomes are structural protein complexes localized at the interface of tissues with
high mechanical demand and shear forces. Beyond tissue anchoring, hemidesmosomes …